ArticleTranslational vision science & technology2020
Subretinal Fibrosis Detection Using Polarization Sensitive Optical Coherence Tomography.
Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Imaging and functional correlates of fibrosis in neovascular age-related macular degeneration: a systematic review.Frontiers in ophthalmology · 2026Pooled it
- Management of fibrosis in neovascular age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Polarization-Sensitive OCT Assessment of Retinal Emboli in Branch Retinal Artery Occlusion: A Pilot Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Recent Advances in Ophthalmic Imaging: A Decade in ReviewCurrent medical imaging · 2026Article
- Nintedanib Induces Mesenchymal-to-Epithelial Transition and Reduces Subretinal Fibrosis Through Metabolic Reprogramming.International journal of molecular sciences · 2025Article
- Imaging biomarkers and artificial intelligence for diagnosis, prediction, and therapy of macular fibrosis in age-related macular degeneration: Narrative review and future directions.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Whorl-Like Collagen Fiber Arrangement Around Emissary Canals in the Posterior Sclera.Investigative ophthalmology & visual science · 2025Article
- Relationship Between Intraocular Pressure-Lowering Effects and Alterations in Anterior Segment Scleral Birefringence Following Micropulse Cyclophotocoagulation.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Fibrosis in age-related neovascular macular degeneration in the anti-VEGF era.Eye (London, England) · 2024Review
- Structure-Function Correlation of Retinal Fibrosis in Eyes with Neovascular Age-Related Macular Degeneration.Journal of clinical medicine · 2024Article
- Polarization-sensitive optical coherence tomography for renal tumor detection inOptics and lasers in engineering · 2024Article
- Enhancing epidural needle guidance using a polarization-sensitive optical coherence tomography probe with convolutional neural networks.Journal of biophotonics · 2024Article
- Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative Study.Biomolecules · 2023Article
- Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration.Scientific reports · 2022Observational
- Morphologic and Microvascular Differences Between Macular Neovascularization With and Without Subretinal Fibrosis.Translational vision science & technology · 2021Article
- Identification and quantification of fibrotic areas in the human retina using polarization-sensitive OCT.Biomedical optics express · 2021Article
- Article
- Advances in multimodal imaging in ophthalmology.Therapeutic advances in ophthalmologyReview
- Evaluation of Reticular Pseudodrusen by Polarization-Sensitive Optical Coherence Tomography: Case Report.Case reports in ophthalmologyArticle
- Quantification of Hyperreflective Foci in Age-related Macular Degeneration by Polarization-Sensitive OCT.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Subretinal fibrosis (SRFib) is an important cause of permanent loss-of-vision diseases with submacular neovascularization, but a reliable diagnostic method is currently missing. This study uses polarization-sensitive optical coherence tomography (PS-OCT) to detect SRFib within retinal lesions by measurement of its birefringent collagen fibers. Methods: Twenty-five patients were enrolled with retinal pathology in one or both eyes containing (1) suspected SRFib, (2) lesions suspected not to be fibrotic, or (3) lesions with doubtful presence of SRFib. All eyes were evaluated for SRFIb using conventional diagnostics by three retinal specialists. PS-OCT images were visually evaluated for SRFib based on cumulative phase retardation, local birefringence, and optic axis uniformity. Results: Twenty-nine eyes from 22 patients were scanned successfully. In 13 eyes, SRFib was diagnosed by all retinal specialists; of these, 12 were confirmed by PS-OCT and one was inconclusive. In nine eyes, the retinal specialists expected no SRFib, which was confirmed by PS-OCT in all cases. In seven eyes, the retinal specialists' evaluations were inconsistent with regard to the presence of SRFib. PS-OCT confirmed the presence of SRFib in four of these eyes and the absence of SRFib in two eyes and was inconclusive in one eye. Conclusions: In 21 out of 22 eyes, PS-OCT confirmed the evaluation of retinal specialists regarding the presence of SRFib. PS-OCT provided additional information to distinguish SRFib from other tissues within subretinal neovascular lesions in 6 out of 7 eyes. Translational Relevance: PS-OCT can identify and quantify SRFib in doubtful cases for which a reliable diagnosis is currently lacking.
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