Evidence map›Paper›PMID 32817969›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Detection, prevalence, and duration of humoral responses to SARS-CoV-2 under conditions of limited population exposure.

Tyler J Ripperger, Jennifer L Uhrlaub, Makiko Watanabe, Rachel Wong, Yvonne Castaneda, Hannah A Pizzato, Mallory R Thompson, Christine Bradshaw, Craig C Weinkauf, Christian Bime and 27 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 39 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors at 2 institutions in 1 country.

Tyler J RippergerDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Jennifer L UhrlaubDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Makiko WatanabeDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Rachel WongDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Yvonne CastanedaDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Hannah A PizzatoDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Mallory R ThompsonDepartment of Surgery, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Christine BradshawDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Craig C WeinkaufDepartment of Surgery, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Christian BimeDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Heidi L EricksonDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Kenneth KnoxDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Billie BixbyDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Sairam ParthasarathyDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Sachin ChaudharyDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Bhupinder NattDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Elaine CristanDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Tammer El AiniDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Franz RischardDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Janet CampionDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Madhav ChopraDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Michael InselDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Afshin SamDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
James L KneplerDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Andrew P CapaldiDepartment of Molecular and Cellular Biology, University of Arizona - Tucson, Tucson, AZ, USA.
Catherine M SpierDepartment of Pathology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Michael D DakeOffice of the Senior Vice-President for Health Sciences, University of Arizona, Tucson, USA.
Taylor EdwardsUniversity of Arizona Genomics Core, University of Arizona, Tucson, AZ and the Arizona Research Labs, University of Arizona Genetics Core, University of Arizona, Tucson, AZ, USA.
Matthew E KaplanFunctional Genomics Core, University of Arizona, Tucson, AZ.
Serena Jain ScottDivision of Geriatrics, General Medicine and Palliative Care, Department of Medicine, University of Arizona College of Medicine-Tucson, Tucson, USA.
Cameron HypesDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Jarrod MosierDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
David T HarrisDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Bonnie J LaFleurBIO5 Institute, University of Arizona, Tucson, USA.
Ryan SprisslerUniversity of Arizona Genomics Core, University of Arizona, Tucson, AZ and the Arizona Research Labs, University of Arizona Genetics Core, University of Arizona, Tucson, AZ, USA.
Janko Nikolich-ŽugichDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
Deepta BhattacharyaDepartment of Immunobiology, University of Arizona College of Medicine - Tucson, Tucson, AZ, USA.
University of Arizona · USTranslational Genomics Research Institute · US

Funding

TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITYR01AI099108 · NIAID · WASHINGTON UNIVERSITY · PI Deepta Bhattacharya · 2012 to 2026
$6.4M
GLUCOSE AND AMINO ACID CATABOLISM IN PLASMA CELL BIOLOGYR01AI129945 · NIAID · UNIVERSITY OF ARIZONA · PI Deepta Bhattacharya · 2018 to 2026
$4.8M
T Cell Homeostasis and Function in Immune SenescenceR37AG020719 · NIA · UNIVERSITY OF ARIZONA · PI JANKO Z. NIKOLICH · 2018 to 2026
$4.2M
T Cell Homeostasis and Function in Immune SenescenceR01AG020719 · NIA · UNIVERSITY OF ARIZONA · PI NIKOLICH, JANKO Z. · 2001 to 2012
$3.1M
Mechanisms of age-related susceptibility to the chikungunya virus (CHIKV)R01AG057701 · NIA · UNIVERSITY OF ARIZONA · PI NIKOLICH, JANKO Z. · 2018 to 2022
$1.7M
SELPLG as a candidate gene in Acute Respiratory Distress SyndromeK08HL141623 · NHLBI · UNIVERSITY OF ARIZONA · PI BIME, CHRISTIAN · 2018 to 2022
$863k
NHLBI NIH HHS K08 HL141623NIAID NIH HHS R01 AI099108NIAID NIH HHS R01 AI129945NIA NIH HHS R01 AG020719NIA NIH HHS R01 AG057701NIA NIH HHS R37 AG020719
6 · The paper itself

Abstract

We conducted an extensive serological study to quantify population-level exposure and define correlates of immunity against SARS-CoV-2. We found that relative to mild COVID-19 cases, individuals with severe disease exhibited elevated authentic virus-neutralizing titers and antibody levels against nucleocapsid (N) and the receptor binding domain (RBD) and the S2 region of spike protein. Unlike disease severity, age and sex played lesser roles in serological responses. All cases, including asymptomatic individuals, seroconverted by 2 weeks post-PCR confirmation. RBD- and S2-specific and neutralizing antibody titers remained elevated and stable for at least 2-3 months post-onset, whereas those against N were more variable with rapid declines in many samples. Testing of 5882 self-recruited members of the local community demonstrated that 1.24% of individuals showed antibody reactivity to RBD. However, 18% (13/73) of these putative seropositive samples failed to neutralize authentic SARS-CoV-2 virus. Each of the neutralizing, but only 1 of the non-neutralizing samples, also displayed potent reactivity to S2. Thus, inclusion of multiple independent assays markedly improved the accuracy of antibody tests in low seroprevalence communities and revealed differences in antibody kinetics depending on the viral antigen. In contrast to other reports, we conclude that immunity is durable for at least several months after SARS-CoV-2 infection.

Identifiers

PMID32817969
PMCPMC7430613
OpenAlexW3049009497

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.