Evidence map›Paper›PMID 32817962›Full record

ArticlemedRxiv : the preprint server for health sciences2020

ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition.

Julia S El-Sayed Moustafa, Anne U Jackson, Sarah M Brotman, Li Guan, Sergio Villicaña, Amy L Roberts, Antonino Zito, Lori Bonnycastle, Michael R Erdos, Narisu Narisu and 16 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 4 countries.

Julia S El-Sayed MoustafaDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Sarah M BrotmanDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Li GuanDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Sergio VillicañaDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Amy L RobertsDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Antonino ZitoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Lori BonnycastleNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Michael R ErdosNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Narisu NarisuNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Ryan WelchDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Tingfen YanNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Timo LakkaInstitute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland.
Stephen ParkerDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Jaakko TuomilehtoPublic Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Francis S CollinsNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Päivi PajukantaDepartment of Human Genetics and Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Heikki A KoistinenDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Markku LaaksoDepartment of Medicine, University of Eastern Finland, Kuopio, Finland.
Mario FalchiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Laura J ScottDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Kerrin S SmallDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
University of Michigan · USKing's College London · GBNational Institutes of Health · USUniversity of Eastern Finland · FIUniversity of Helsinki · FIUniversity of North Carolina at Chapel Hill · USHarvard University · US

Funding

Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVIS, RICHARD C · 1985 to 2019
$50.2M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
Genetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2M
GENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Intramural NIH HHS Z01 HG000024Intramural NIH HHS ZIA HG000024Medical Research Council MR/M004422/1NHLBI NIH HHS P01 HL028481NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIGMS NIH HHS T32 GM007092Wellcome Trust
6 · The paper itself

Abstract

COVID-19 severity has varied widely, with demographic and cardio-metabolic factors increasing risk of severe reactions to SARS-CoV-2 infection, but the underlying mechanisms for this remain uncertain. We investigated phenotypic and genetic factors associated with subcutaneous adipose tissue expression of Angiotensin I Converting Enzyme 2 (

Identifiers

PMID32817962
PMCPMC7430606
OpenAlexW3048848460

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.