Evidence map›Paper›PMID 32817947›Full record

ArticlebioRxiv : the preprint server for biology2020

The interplay of SARS-CoV-2 evolution and constraints imposed by the structure and functionality of its proteins.

Lukasz Jaroszewski, Mallika Iyer, Arghavan Alisoltani, Mayya Sedova, Adam Godzik

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 18 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lukasz JaroszewskiDivision of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521.
Mallika IyerGraduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Arghavan AlisoltaniDivision of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521.
Mayya SedovaDivision of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521.
Adam GodzikDivision of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521.
University of California, Riverside · USSanford Burnham Prebys Medical Discovery Institute · US

Funding

Understanding structural flexibility and evolutionary divergence of proteinsR35GM118187 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GODZIK, ADAM · 2016 to 2020
$1.9M
NIAID NIH HHS HHSN272201700060CNIGMS NIH HHS R35 GM118187
6 · The paper itself

Abstract

Fast evolution of the SARS-CoV-2 virus provides us with unique information about the patterns of genetic changes in a single pathogen in the timescale of months. This data is used extensively to track the phylodynamic of the pandemic's spread and its split into distinct clades. Here we show that the patterns of SARS-CoV-2 virus mutations along its genome are closely correlated with the structural features of the coded proteins. We show that the foldability of proteins' 3D structures and conservation of their functions are the universal factors driving evolutionary selection in protein-coding genes. Insights from the analysis of mutation distribution in the context of the SARS-CoV-2 proteins' structures and functions have practical implications including evaluating potential antigen epitopes or selection of primers for PCR-based COVID-19 tests.

Identifiers

PMID32817947
PMCPMC7430578
OpenAlexW3048056153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.