ArticleBioactive materials2021
Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 121 citations in OpenAlex.
- Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Engineering Multiscale Vasculature: Biological Principles, Design Constraints, and Advanced Biofabrication Strategies for Functional Vascular Networks.Biomimetics (Basel, Switzerland) · 2026Review
- Endoscopic-Assisted Posterior Atlantoaxial Fusion: Technical Innovation and Clinical Experience.Orthopaedic surgery · 2026Article
- Peptide-conjugated biodegradable polyester scaffolds for bone regeneration.Biomaterials · 2026Review
- Cryo-printed collagen scaffolds reinforced with dentin-derived bioactive particles promote osteo-angiogenic bone regeneration.Materials today. Bio · 2026Article
- Advances in Composite Bioactive Scaffolds for Alveolar Bone Repair: Implications for Oral Surgery.Brazilian dental journal · 2026Review
- Hierarchical chirality of bone cement drives osteoinduction via integrin dependent signaling to accelerate critical bone defect regeneration.Journal of nanobiotechnology · 2025Article
- Functionalization of 3D printed PLGA-based scaffolds for bone regeneration.Regenerative therapy · 2025Review
- Synergistic Angio-Osteogenic Effects of Copper-Releasing 3D Biocomposite Scaffolds: A Step Toward Vascularized Bone Regeneration.Research square · 2025Article
- Topology in Biological Piezoelectric Materials.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Recent Advances in Peptide-Functionalized Hydrogels for Bone Tissue Engineering.ACS biomaterials science & engineering · 2025Review
- Application and Mechanism of Adipose Tissue-Derived Microvascular Fragments in Tissue Repair and Regeneration.Biomolecules · 2025Review
- [Hip surgery: 3D printed implants in revision arthroplasty].Orthopadie (Heidelberg, Germany) · 2025Review
- A Review of the Development of Biopolymer Hydrogel-Based Scaffold Materials for Drug Delivery and Tissue Engineering Applications.Gels (Basel, Switzerland) · 2025Review
- Integrating synthetic polypeptides with innovative material forming techniques for advanced biomedical applications.Journal of nanobiotechnology · 2025Review
- 3D-printed artificial bone scaffolds: the design of materials, the incorporation of bioactive substances, and the integration of vascularized tissue flaps.Frontiers in bioengineering and biotechnology · 2025Review
- Advances in 3D-Printed scaffolds for bone defect repair: material strategies and synergistic functional performance.Frontiers in bioengineering and biotechnology · 2025Review
- Imidazole functionalized photo-crosslinked aliphatic polycarbonate drug-eluting coatings on zinc alloys for osteogenesis, angiogenesis, and bacteriostasis in bone regeneration.Bioactive materials · 2024Article
- Crosslinking strategies for biomimetic hydrogels in bone tissue engineering.Biophysical reviews · 2023Review
- Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds.Nano-micro letters · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional (3D) printing has been increasingly employed to produce advanced bone tissue engineering scaffolds with biomimetic structures and matched mechanical strengths, in order to induce improved bone regeneration in defects with a critical size. Given that the successful bone regeneration requires both excellent osteogenesis and vascularization, endowing scaffolds with both strong bone forming ability and favorable angiogenic potential would be highly desirable to induce improved bone regeneration with required vascularization. In this investigation, customized bone tissue engineering scaffolds with balanced osteoconductivity/osteoinductivity were produced via cryogenic 3D printing of β-tricalcium phosphate and osteogenic peptide (OP) containing water/poly(lactic-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.