ArticleApplied physics letters2020
A predictive model of the temperature-dependent inactivation of coronaviruses.
Article in Applied physics letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Trial
- The Nature of Non-Arrhenius Kinetics in the Heat Denaturation of Proteins.International journal of molecular sciences · 2026Article
- Climate change and infectious diseases.Nature medicine · 2026Review
- Short-time thermal inactivation of surrogates of the public transport microbiome with a low-cost thermoresistometer.Scientific reports · 2026Article
- Seasonality of endemic COVID-19.mBio · 2023Article
- Article
- Rapid In Situ Thermal Decontamination of Wearable Composite Textile Materials.ACS applied materials & interfaces · 2023Article
- The Nature of the Enthalpy-Entropy Compensation and "Exotic" Arrhenius Parameters in the Denaturation Kinetics of Proteins.International journal of molecular sciences · 2023Article
- Manipulation, Sampling and Inactivation of the SARS-CoV-2 Virus Using Nonuniform Electric Fields on Micro-Fabricated Platforms: A Review.Micromachines · 2023Review
- Transmission of SARS-CoV-2 in the workplace: Key findings from a rapid review of the literature.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2023Article
- Understanding the role of water on temperature-dependent structural modifications of SARS CoV-2 main protease binding sites.Journal of molecular liquids · 2022Article
- Theoretical Explanation for the Rarity of Antibody-Dependent Enhancement of Infection (ADE) in COVID-19.International journal of molecular sciences · 2022Article
- Evaluation of the combined effect of mobility and seasonality on the COVID-19 pandemic: a Lombardy-based study.Acta bio-medica : Atenei Parmensis · 2022Article
- A general theory for temperature dependence in biology.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Efficacy and self-similarity of SARS-CoV-2 thermal decontamination.Journal of hazardous materials · 2022Article
- Rapid thermal inactivation of aerosolized SARS-CoV-2.Journal of virological methods · 2022Article
- Review of air disinfection approaches and proposal for thermal inactivation of airborne viruses as a life-style and an instrument to fight pandemics.Applied thermal engineering · 2022Review
- Photothermal inactivation of universal viral particles by localized surface plasmon resonance mediated heating filter membrane.Scientific reports · 2022Article
- COVID-19 mortality and exposure to airborne PMThe Science of the total environment · 2022Article
- Determination of the denaturation temperature of the Spike protein S1 of SARS-CoV-2 (2019 nCoV) by Raman spectroscopy.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic has stressed healthcare systems and supply lines, forcing medical doctors to risk infection by decontaminating and reusing single-use personal protective equipment. The uncertain future of the pandemic is compounded by limited data on the ability of the responsible virus, SARS-CoV-2, to survive across various climates, preventing epidemiologists from accurately modeling its spread. However, a detailed thermodynamic analysis of experimental data on the inactivation of SARS-CoV-2 and related coronaviruses can enable a fundamental understanding of their thermal degradation that will help model the COVID-19 pandemic and mitigate future outbreaks. This work introduces a thermodynamic model that synthesizes existing data into an analytical framework built on first principles, including the rate law for a first-order reaction and the Arrhenius equation, to accurately predict the temperature-dependent inactivation of coronaviruses. The model provides much-needed thermal decontamination guidelines for personal protective equipment, including masks. For example, at 70 °C, a 3-log (99.9%) reduction in virus concentration can be achieved, on average, in 3 min (under the same conditions, a more conservative decontamination time of 39 min represents the upper limit of a 95% interval) and can be performed in most home ovens without reducing the efficacy of typical N95 masks as shown in recent experimental reports. This model will also allow for epidemiologists to incorporate the lifetime of SARS-CoV-2 as a continuous function of environmental temperature into models forecasting the spread of the pandemic across different climates and seasons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.