ArticleProceedings of the National Academy of Sciences of the United States of America2020
Divergence of rodent and primate medial frontal cortex functional connectivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.Nature communications · 2022Pooled it
- The Role of Kappa-Opioid Receptor/Dynorphin System in Modulating Neural-Circuits of Depression and Anxiety-A Review.Journal of cellular and molecular medicine · 2026Review
- Modulating auditory attention and stimulus evaluation in the medial prefrontal cortex: A translational tone approach oddball paradigm in rats.Cognitive, affective & behavioral neuroscience · 2026Article
- Noninvasive Focal Gene Delivery of Functional Neural Actuators to the Primate Spinal Cord using Focused Ultrasound.bioRxiv : the preprint server for biology · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- The Anatomical Connections of Nucleus Accumbens with Brainstem and Cerebellum in the Rat and Human Subjects.Cerebellum (London, England) · 2026Article
- Noninvasive focal gene transfer of chemogenetic proteins in the primate brain.Cell reports methods · 2026Article
- Behavioral and brain-wide neural signatures of sundowning in Alzheimer's disease.Research square · 2026Article
- Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices.Communications biology · 2026Article
- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
- Differential representations of spatial environments in mPFC and hippocampus underpinning flexible navigation.NeuroImage · 2026Article
- TransBrain: a computational framework for translating brain-wide phenotypes between humans and mice.Nature methods · 2026Article
- The role of the anterior cingulate cortex in anxiety control, from circuits to disorders.Frontiers in psychiatry · 2026Review
- Stem Cell Models for Elucidating Cellular Mechanisms of Substance Use Disorders and Advancing Addiction Pharmacology.Stem cells international · 2026Review
- Parallel encoding of speech in human frontal and temporal lobes.Nature communications · 2025Article
- Recent advances in model systems for interrogating diseases of brain aging and associated dementia: Toward human-relevant endophenotypes.Current opinion in neurobiology · 2025Review
- An open access resource for marmoset neuroscientific apparatus.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse.PloS one · 2025Article
- The Continuing Challenges of Studying Parallel Behaviours in Humans and Animal Models.Current topics in behavioral neurosciences · 2025Review
- Comparing mouse and human cingulate cortex organization using functional connectivity.Brain structure & function · 2024Article
6 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
With the medial frontal cortex (MFC) centrally implicated in several major neuropsychiatric disorders, it is critical to understand the extent to which MFC organization is comparable between humans and animals commonly used in preclinical research (namely rodents and nonhuman primates). Although the cytoarchitectonic structure of the rodent MFC has mostly been conserved in humans, it is a long-standing question whether the structural analogies translate to functional analogies. Here, we probed this question using ultra high field fMRI data to compare rat, marmoset, and human MFC functional connectivity. First, we applied hierarchical clustering to intrinsically define the functional boundaries of the MFC in all three species, independent of cytoarchitectonic definitions. Then, we mapped the functional connectivity "fingerprints" of these regions with a number of different brain areas. Because rats do not share cytoarchitectonically defined regions of the lateral frontal cortex (LFC) with primates, the fingerprinting method also afforded the unique ability to compare the rat MFC and marmoset LFC, which have often been suggested to be functional analogs. The results demonstrated remarkably similar intrinsic functional organization of the MFC across the species, but clear differences between rodent and primate MFC whole-brain connectivity. Rat MFC patterns of connectivity showed greatest similarity with premotor regions in the marmoset, rather than dorsolateral prefrontal regions, which are often suggested to be functionally comparable. These results corroborate the viability of the marmoset as a preclinical model of human MFC dysfunction, and suggest divergence of functional connectivity between rats and primates in both the MFC and LFC.
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