ArticleProceedings of the National Academy of Sciences of the United States of America2020
Compression stiffening of fibrous networks with stiff inclusions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Pooled it
- Conformational dynamics of exopolysaccharides underlie biofilm matrix mechanics inbioRxiv : the preprint server for biology · 2026Article
- Ordered nanoplastic-elastomer networks resolve conflict between softness and stability.Nature communications · 2026Article
- Soft tissue mechanosensing and remodeling: the core regulatory role of Piezo/TRPV4 ion channels.Frontiers in cell and developmental biology · 2026Review
- Shear and Compressive Stiffening of Dual-Cross-Linked Alginate Hydrogels with Tunable Viscoelasticity.ACS applied bio materials · 2025Article
- Rheological Investigation of Polydimethylsiloxane with Glass Beads: A Model for Compression-Stiffening Effects in Soft Tissue Engineering.Materials (Basel, Switzerland) · 2025Article
- Bacteria Colonies Modify Their Shear and Compressive Mechanical Properties in Response to Different Growth Substrates.ACS applied bio materials · 2024Article
- Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application.International journal of molecular sciences · 2024Review
- Hyperelasticity of blood clots: Bridging the gap between microscopic and continuum scales.Journal of the mechanics and physics of solids · 2024Article
- Unexpected softening of a fibrous matrix by contracting inclusions.Acta biomaterialia · 2024Article
- Elasticity-controlled jamming criticality in soft composite solids.Nature communications · 2024Article
- Clots reveal anomalous elastic behavior of fiber networks.Science advances · 2024Article
- Topological damping in an ultrafast giant cell.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dynamic remodeling of fiber networks with stiff inclusions under compressive loading.Acta biomaterialia · 2023Article
- Hyperelastic continuum models for isotropic athermal fibrous networks.Interface focus · 2022Article
- Modulation of Biofilm Mechanics by DNA Structure and Cell Type.ACS biomaterials science & engineering · 2022Article
- Article
- Rheology of marine sponges reveals anisotropic mechanics and tuned dynamics.Journal of the Royal Society, Interface · 2022Article
- Unique Role of Vimentin Networks in Compression Stiffening of Cells and Protection of Nuclei from Compressive Stress.Nano letters · 2022Article
- Materials science and mechanosensitivity of living matter.Applied physics reviews · 2022Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissues commonly consist of cells embedded within a fibrous biopolymer network. Whereas cell-free reconstituted biopolymer networks typically soften under applied uniaxial compression, various tissues, including liver, brain, and fat, have been observed to instead stiffen when compressed. The mechanism for this compression-stiffening effect is not yet clear. Here, we demonstrate that when a material composed of stiff inclusions embedded in a fibrous network is compressed, heterogeneous rearrangement of the inclusions can induce tension within the interstitial network, leading to a macroscopic crossover from an initial bending-dominated softening regime to a stretching-dominated stiffening regime, which occurs before and independently of jamming of the inclusions. Using a coarse-grained particle-network model, we first establish a phase diagram for compression-driven, stretching-dominated stress propagation and jamming in uniaxially compressed two- and three-dimensional systems. Then, we demonstrate that a more detailed computational model of stiff inclusions in a subisostatic semiflexible fiber network exhibits quantitative agreement with the predictions of our coarse-grained model as well as qualitative agreement with experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.