Evidence map›Paper›PMID 32817449›Full record

ArticlemSphere2020

Redesigned TetR-Aptamer System To Control Gene Expression in Plasmodium falciparum.

Krithika Rajaram, Hans B Liu, Sean T Prigge

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  12. Genetic analysis of pyrimidine biosynthetic enzymes inbioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. MappingbioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. tRNA modifying enzymes MnmE and MnmG are essential forbioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. eLife · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Krithika RajaramDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Hans B LiuDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Sean T PriggeDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA sprigge2@jhu.edu.ORCID 0000-0001-9684-1733
Johns Hopkins University · US

Funding

Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Determinants of apicoplast maintenance in malaria parasitesR01AI125534 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sean Taylor PRIGGE · 2016 to 2026
$3.9M
Roles of Lipoate Pathways in Plasmodium SurvivalR01AI065853 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PRIGGE, SEAN TAYLOR · 2006 to 2010
$2.0M
NIAID NIH HHS R01 AI065853NIAID NIH HHS R01 AI125534NIAID NIH HHS T32 AI007417
6 · The paper itself

Abstract

One of the most powerful approaches to understanding gene function involves turning genes on and off at will and measuring the impact at the cellular or organismal level. This particularly applies to the cohort of essential genes where traditional gene knockouts are inviable. In

Indexed as

Genes, EssentialAptamers, NucleotideGene Expression RegulationOligonucleotide Array Sequence AnalysisPlasmodium falciparumProof of Concept StudyRNA, MessengerTetracyclineTrans-ActivatorsAptamers, NucleotideRNA, MessengerTetracyclineTrans-Activatorsmalariaprotein knockdownRNA aptamerstetracyclinetetracycline repressorTetR-DOZI

Identifiers

PMID32817449
PMCPMC7426165
OpenAlexW3048502692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.