Evidence map›Paper›PMID 32817447›Full record

ArticleRNA (New York, N.Y.)2020

Processing of

Yusuke Shiromoto, Masayuki Sakurai, Helen Qu, Andrew V Kossenkov, Kazuko Nishikura

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Transposon control as a checkpoint for tissue regeneration.Development (Cambridge, England) · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. The role of RNA editing enzyme ADAR1 in human disease.Wiley interdisciplinary reviews. RNA · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yusuke ShiromotoThe Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Masayuki SakuraiThe Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Helen QuThe Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Andrew V KossenkovThe Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Kazuko NishikuraThe Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
The Wistar Institute · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASER01GM040536 · NIGMS · WISTAR INSTITUTE · PI NISHIKURA, KAZUKO · 1991 to 2021
$8.1M
Control of Breast Cancer Metastasis by Epstein-Barr Virus microRNAR01CA175058 · NCI · WISTAR INSTITUTE · PI NISHIKURA, KAZUKO · 2014 to 2018
$2.0M
Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6M
Stress Response Functions of ADAR1 Regulated by MAP KinasesR01GM130716 · NIGMS · WISTAR INSTITUTE · PI NISHIKURA, KAZUKO · 2019 to 2022
$1.5M
NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA175058NCI NIH HHS R50 CA211199NIGMS NIH HHS R01 GM040536NIGMS NIH HHS R01 GM130716
6 · The paper itself

Abstract

In addition to adenosine-to-inosine RNA editing activities, ADAR1 has been shown to have various RNA editing-independent activities including modulation of RNAi efficacy. We previously reported that ADAR1 forms a heterodimer complex with DICER and facilitates processing of pre-miRNAs to mature miRNAs. In addition to miRNA synthesis, DICER is involved in processing of long dsRNAs into small RNAs (endo-siRNAs). Generation of retrotransposon-derived endo-siRNAs by DICER and their functions in regulation of transcripts in mouse oocytes has been previously reported. However, the synthesis and functions of endo-siRNAs in somatic cells remain largely unknown. Here, we report that ADAR1 together with DICER generates endogenous small RNAs,

Indexed as

Alu ElementsRNA Processing, Post-Transcriptional3' Untranslated RegionsAdenosine DeaminaseArgonaute ProteinsDEAD-box RNA HelicasesHeLa CellsHep G2 CellsHumansNucleic Acid ConformationRibonuclease IIIRNARNA-Binding ProteinsRNA EditingRNA, Small Interfering3' Untranslated RegionsADAR protein, humanAdenosine DeaminaseAGO2 protein, humanArgonaute ProteinsDEAD-box RNA HelicasesDICER1 protein, humanRibonuclease IIIRNARNA-Binding ProteinsRNA, Small InterferingADAR1AluDICERRNA editingRNAisiRNA

Identifiers

PMID32817447
PMCPMC7668262
OpenAlexW3061699781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.