ReviewProceedings of the National Academy of Sciences of the United States of America2020
Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed.
- Sibling chimerism among microglia in marmosets.eLife · 2026Article
- Crosstalk-free optical indicator-actuator combinations for bidirectional optogenetics.npj biomedical innovations · 2026Review
- Combining phase analysis and causal stimulation enables longitudinal mesoscale connectivity mapping.bioRxiv : the preprint server for biology · 2026Article
- Comparative Mapping of Functional and Structural Homologies in the Pig and Human Brain.bioRxiv : the preprint server for biology · 2026Article
- Projection-specific intersectional optogenetics for precise excitation and inhibition in the marmoset brain.Cell reports methods · 2026Article
- Incorporating farm animal models for the study of neuropsychiatric diseases: Expansion of the possibilities.Cognitive, affective & behavioral neuroscience · 2026Review
- Targeted gene transfer into developmentally defined cell populations of the primate brain.Cell reports · 2026Article
- Long-term effects of forty-hertz auditory stimulation as a treatment of Alzheimer's disease: Insights from an aged monkey model study.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Developmental trajectories of vocal behaviors in common marmosets as a reference framework for neurobehavioral studies.Frontiers in neural circuits · 2026Article
- Longitudinal Characterization of GiantResearch (Washington, D.C.) · 2026Article
- multiVIB: A unified probabilistic contrastive learning framework for atlas-scale integration of single-cell multi-omics data.bioRxiv : the preprint server for biology · 2025Article
- Accelerated senescence animal models and application in dentistry: A scoping review.Journal of dental sciences · 2025Review
- ATM deficiency drives phenotypic diversity and Purkinje cell degeneration in a macaque model of ataxia-telangiectasia.Cell reports. Medicine · 2025Article
- Article
- RNA-programmable cell-type monitoring and manipulation in the human cortex with CellREADR.Cell reports · 2025Article
- Review
- A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types.Cell · 2025Article
- Review
- Single-Neuron Reconstruction of the Macaque Primary Motor Cortex Reveals the Diversity of Neuronal Morphology.Neuroscience bulletin · 2025Article
- Benchmarking macaque brain gene expression for horizontal and vertical translation.Science advances · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The recently developed new genome-editing technologies, such as the CRISPR/Cas system, have opened the door for generating genetically modified nonhuman primate (NHP) models for basic neuroscience and brain disorders research. The complex circuit formation and experience-dependent refinement of the human brain are very difficult to model in vitro, and thus require use of in vivo whole-animal models. For many neurodevelopmental and psychiatric disorders, abnormal circuit formation and refinement might be at the center of their pathophysiology. Importantly, many of the critical circuits and regional cell populations implicated in higher human cognitive function and in many psychiatric disorders are not present in lower mammalian brains, while these analogous areas are replicated in NHP brains. Indeed, neuropsychiatric disorders represent a tremendous health and economic burden globally. The emerging field of genetically modified NHP models has the potential to transform our study of higher brain function and dramatically facilitate the development of effective treatment for human brain disorders. In this paper, we discuss the importance of developing such models, the infrastructure and training needed to maximize the impact of such models, and ethical standards required for using these models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.