Evidence map›Paper›PMID 32817433›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

One gene, multiple ecological strategies: A biofilm regulator is a capacitor for sustainable diversity.

Eisha Mhatre, Daniel J Snyder, Emily Sileo, Caroline B Turner, Sean W Buskirk, Nicolas L Fernandez, Matthew B Neiditch, Christopher M Waters, Vaughn S Cooper

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Genetic diversification ofApplied and environmental microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Mechanisms of antimicrobial resistance in biofilms.npj antimicrobials and resistance · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Pellicle Biofilm Formation inJournal of bacteriology · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Eisha MhatreDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.ORCID 0000-0001-7203-2632
Daniel J SnyderDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.
Emily SileoDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.ORCID 0000-0003-3032-7373
Caroline B TurnerDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.
Sean W BuskirkDepartment of Biology, West Chester University of Pennsylvania, West Chester, PA 19383.ORCID 0000-0003-1213-8130
Nicolas L FernandezDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824.
Matthew B NeiditchDepartment of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, NJ 07103.ORCID 0000-0002-7039-4469
Christopher M WatersDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824.
Vaughn S CooperDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219; vaughn.cooper@pitt.edu.ORCID 0000-0001-7726-0765
University of Pittsburgh · USMichigan State University · USRutgers, The State University of New Jersey · USWest Chester University · US

Funding

Molecular mechanisms of adaptive diversity in Burkholderia biofilmsR01GM110444 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, VAUGHN · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM110444
6 · The paper itself

Abstract

Many bacteria cycle between sessile and motile forms in which they must sense and respond to internal and external signals to coordinate appropriate physiology. Maintaining fitness requires genetic networks that have been honed in variable environments to integrate these signals. The identity of the major regulators and how their control mechanisms evolved remain largely unknown in most organisms. During four different evolution experiments with the opportunist betaproteobacterium

Indexed as

Bacterial ProteinsBiofilmsBurkholderia cenocepaciaCyclic GMPDirected Molecular EvolutionGene Expression Regulation, BacterialMutationPhenotypeQuorum SensingSignal TransductionVirulenceBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPbiofilmBurkholderiacyclic-di-GMPdiversificationexperimental evolution

Identifiers

PMID32817433
PMCPMC7474642
OpenAlexW3064087220

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.