ArticleProceedings of the National Academy of Sciences of the United States of America2020
Ultraflexible organic light-emitting diodes for optogenetic nerve stimulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 76 citations in OpenAlex.
- Hybrid Liquid Metal Cathode Enables High-Performance Intrinsically Stretchable OLEDs.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Optogenetic Strategies for Motor Recovery After Ischemic Stroke: Mechanisms and Therapeutic Implications.Cellular and molecular neurobiology · 2026Review
- High-power pulsed electrochemiluminescence for optogenetic manipulation of Drosophila larval behaviour.Light, science & applications · 2026Article
- Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Challenges and opportunities in next-generation LED therapeutic devices.Light, science & applications · 2025Review
- Review
- Fully biocompatible, thermally drawn fiber supercapacitors for long-term bio-implantation.Nature communications · 2025Article
- Development of a Biodegradable Green Emitter Chitosan-Based OLED for Implantable Biomedical Devices.ACS applied materials & interfaces · 2025Article
- Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems.Bioactive materials · 2025Review
- Organic Bioelectronics in Microphysiological Systems: Bridging the Gap Between Biological Systems and Electronic Technologies.Biosensors · 2025Review
- Advancing Cancer Treatment and Diagnosis: A Review on Photodynamic Therapy Using OLED Technology.Molecules (Basel, Switzerland) · 2025Review
- Human-Centric, Three Dimensional Micro Light-Emitting Diodes for Cosmetic and Medical Phototherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Wireless magnetoelectrically powered organic light-emitting diodes.Science advances · 2024Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- OLED catheters for inner-body phototherapy: A case of type 2 diabetes mellitus improved via duodenal photobiomodulation.Science advances · 2023Article
- Skin-Inspired Ultra-Tough Supramolecular Multifunctional Hydrogel Electronic Skin for Human-Machine Interaction.Nano-micro letters · 2023Article
- Neural modulation with photothermally active nanomaterials.Nature reviews bioengineering · 2023Article
- Combined optogenetic and electrical stimulation of the sciatic nerve for selective control of sensory fibers.Frontiers in neuroscience · 2023Article
- Flexible Electronics and Devices as Human-Machine Interfaces for Medical Robotics.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organic electronic devices implemented on flexible thin films are attracting increased attention for biomedical applications because they possess extraordinary conformity to curved surfaces. A neuronal device equipped with an organic light-emitting diode (OLED), used in combination with animals that are genetically engineered to include a light-gated ion channel, would enable cell type-specific stimulation to neurons as well as conformal contact to brain tissue and peripheral soft tissue. This potential application of the OLEDs requires strong luminescence, well over the neuronal excitation threshold in addition to flexibility. Compatibility with neuroimaging techniques such as MRI provides a method to investigate the evoked activities in the whole brain. Here, we developed an ultrathin, flexible, MRI-compatible OLED device and demonstrated the activation of channelrhodopsin-2-expressing neurons in animals. Optical stimulation from the OLED attached to nerve fibers induced contractions in the innervated muscles. Mechanical damage to the tissues was significantly reduced because of the flexibility. Owing to the MRI compatibility, neuronal activities induced by direct optical stimulation of the brain were visualized using MRI. The OLED provides an optical interface for modulating the activity of soft neuronal tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.