Evidence map›Paper›PMID 32817420›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Circadian regulation of c-MYC in mice.

Zhenxing Liu, Christopher P Selby, Yanyan Yang, Laura A Lindsey-Boltz, Xuemei Cao, Khagani Eynullazada, Aziz Sancar

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 47 citations in OpenAlex.

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  10. Epitranscriptomic sculpting: the role of mMedical oncology (Northwood, London, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhenxing LiuDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7260.ORCID 0000-0001-8236-1931
Christopher P SelbyDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7260.
Yanyan YangDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7260.
Laura A Lindsey-BoltzDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7260.ORCID 0000-0001-6493-8194
Xuemei CaoDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7260.
Khagani EynullazadaDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7260.ORCID 0000-0002-0702-9055
Aziz SancarDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7260 aziz_sancar@med.unc.edu.ORCID 0000-0001-6469-4900
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Molecular Mechanism of Mammalian DNA Excision Repair, DNA Damage Checkpoints and the Circadian ClockR35GM118102 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AZIZ SANCAR · 2016 to 2026
$10.6M
NCI NIH HHS P30 CA016086NIEHS NIH HHS P30 ES010126NIGMS NIH HHS R35 GM118102
6 · The paper itself

Abstract

The circadian clock is a global regulatory mechanism that controls the expression of 50 to 80% of transcripts in mammals. Some of the genes controlled by the circadian clock are oncogenes or tumor suppressors. Among these

Indexed as

AnimalsARNTL Transcription FactorsCell Cycle ProteinsCircadian ClocksCircadian RhythmCLOCK ProteinsCryptochromesFemaleGene Expression RegulationGenes, mycMaleMiceMice, Inbred C57BLMice, KnockoutOncogenesPeriod Circadian ProteinsARNTL Transcription FactorsCell Cycle ProteinsCLOCK ProteinsCry1 protein, mouseCry2 protein, mouseCryptochromesMyc protein, mousePeriod Circadian ProteinsProto-Oncogene Proteins c-mycBMAL1circadian clockc-MYCcryptochromestranscription regulation

Identifiers

PMID32817420
PMCPMC7474601
OpenAlexW3060793901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.