ArticleScience translational medicine2020
Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency.
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Effect of the modified RADAR, No-touch, and conventional techniques on arteriovenous fistula outcomes.Renal failure · 2026Article
- A Vein Attempt? Experimental Models for Arteriovenous Fistula Research.Cardiovascular engineering and technology · 2026Review
- Predicting haemodialysis arteriovenous fistula outcomes using computational fluid dynamics and ferumoxytol-enhanced MRI.The journal of vascular access · 2026Article
- From Acute Thrombosis to Eccentric Neointima in Arteriovenous Fistula.Seminars in thrombosis and hemostasis · 2026Article
- Characterization of Arteriovenous Thrombus Formation and Propagation in a Mouse Arteriovenous Fistula Model.Thrombosis and haemostasis · 2025Article
- Comparison of the primary outcome of the radial artery deviation and reimplantation technique and the ultrasound-guided percutaneous transluminal angioplasty in the treatment of forearm arteriovenous fistula type I stenosis in haemodialysis patients: a pilot study.International urology and nephrology · 2025Article
- Analysis of arteriovenous fistula failure factors and construction of nomogram prediction model in patients with maintenance hemodialysis.Renal failure · 2025Article
- BACE2-Induced Aberrant Lymphatic Network Aggravates the Local Inflammation in Arteriovenous Fistulas With Hyperphosphatemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Evaluating Animal Models for Improved Hemodialysis Vascular Access: A Focus on Arteriovenous Fistula.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Differential hemodynamics between autogenous arteriovenous fistulas in forearm created by modified no-touch technique and conventional surgery: four-dimensional flow magnetic resonance imaging approach.Quantitative imaging in medicine and surgery · 2025Article
- Role of Perivascular Adipose Tissue in Vein Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Early thrombus formation is required for eccentric and heterogeneous neointimal hyperplasia under disturbed flow.Journal of thrombosis and haemostasis : JTH · 2024Article
- Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia.American journal of physiology. Heart and circulatory physiology · 2024Article
- Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- A central arteriovenous fistula reduces systemic hypertension in a mouse model.JVS-vascular science · 2024Article
- A surgeon-scientist's approach to improving arteriovenous fistula patency.JVS-vascular science · 2024Article
- Article
- RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68.European journal of medical research · 2023Article
- Endothelial mechanobiology in atherosclerosis.Cardiovascular research · 2023Review
- Heterogeneous Maturation of Arterio-Venous Fistulas and Loop-Shaped Venous Interposition Grafts: A Histological and 3D Flow Simulation Comparison.Biomedicines · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Arteriovenous fistulae (AVF) are the preferred mode of hemodialysis access, but 60% of conventional [vein-to-artery (V-A)] AVF fail to mature, and only 50% remain patent at 1 year. We previously showed improved maturation and patency in a pilot study of the radial artery deviation and reimplantation (RADAR) technique that uses an artery-to-vein (A-V) configuration. Here, we show that RADAR exhibits higher rates of maturation, as well as increased primary and secondary long-term patencies. RADAR is also protective in female patients, where it is associated with decreased reintervention rates and improved secondary patency. RADAR and conventional geometries were compared further in a rat bilateral carotid artery-internal jugular vein fistula model. There was decreased cell proliferation and neointimal hyperplasia in the A-V configuration in male and female animals, but no difference in hypoxia between the A-V and V-A configurations. Similar trends were seen in uremic male rats. The A-V configuration also associated with increased peak systolic velocity and expression of Kruppel-like factor 2 and phosphorylated endothelial nitric oxide synthase, consistent with improved hemodynamics. Computed tomography and ultrasound-informed computational modeling showed different hemodynamics in the A-V and V-A configurations, and improving the hemodynamics in the V-A configuration was protective against neointimal hyperplasia. These findings collectively demonstrate that RADAR is a durable surgical option for patients requiring radial-cephalic AVF for hemodialysis access.
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Registered trials
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