Evidence map›Paper›PMID 32817333›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Exhausted CD4

Ana Villegas-Mendez, Garima Khandelwal, Lucy M McGowan, Rebecca S Dookie, Michael J Haley, Charlotte George, David Sims, Graham M Lord, Linda V Sinclair, Richard G Jenner and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. T cell exhaustion in parasitic infections.Frontiers in immunology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Early Expression of Functional Markers on CD4Frontiers in immunology · 2022
    Observational
  10. The Metabolic Basis of ILC Plasticity.Frontiers in immunology · 2022
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ana Villegas-MendezThe Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom.
Garima KhandelwalUniversity College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom.
Lucy M McGowanThe Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom.ORCID 0000-0002-5576-605X
Rebecca S DookieThe Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom.
Michael J HaleyThe Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom.ORCID 0000-0003-2485-8485
Charlotte GeorgeOxford Biomedical Data Science Training Programme, Medical Research Council Wetherall Institute of Molecular Medicine Centre for Computational Biology, Medical Research Council Wetherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom; and.
David SimsOxford Biomedical Data Science Training Programme, Medical Research Council Wetherall Institute of Molecular Medicine Centre for Computational Biology, Medical Research Council Wetherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom; and.
Graham M LordThe Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom.ORCID 0000-0003-2069-4743
Linda V SinclairDivision of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0000-0003-1248-7189
Richard G JennerUniversity College London Cancer Institute, University College London, London WC1E 6DD, United Kingdom.ORCID 0000-0002-2946-6811
Kevin N CouperThe Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom; kevin.couper@manchester.ac.uk.ORCID 0000-0003-4659-8960
University of Manchester · GBJohn Radcliffe Hospital · GBLondon Cancer · GBUniversity of Dundee · GB

Funding

Medical Research Council H4R00700Medical Research Council MC_PC_15065Medical Research Council MR/L008564/1Medical Research Council MR/M003493/1Medical Research Council MR/R001413/1Medical Research Council MR/R010099/1
6 · The paper itself

Abstract

CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesCellular SenescenceGene Expression RegulationGlycolysisHumansImmune Checkpoint InhibitorsImmune ToleranceImmunologic MemoryInterferon-gammaInterleukin-27Lymphocyte ActivationMalariaMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLImmune Checkpoint InhibitorsInterferon-gammaInterleukin-27Mechanistic Target of Rapamycin Complex 1T-bet Transcription FactorT-Box Domain Proteins

Identifiers

PMID32817333
PMCPMC7477746
OpenAlexW3044327194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.