Evidence map›Paper›PMID 32817331›Full record

ArticleInfection and immunity2020

Single Amino Acid Replacements in RocA Disrupt Protein-Protein Interactions To Alter the Molecular Pathogenesis of Group A

Paul E Bernard, Amey Duarte, Mikhail Bogdanov, James M Musser, Randall J Olsen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Defining Membrane Protein Topology Using pho-lac Reporter Fusions.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Paul E BernardCenter for Molecular and Translational Human Infectious Disease Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0002-2838-2739
Amey DuarteCenter for Molecular and Translational Human Infectious Disease Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.
Mikhail BogdanovDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas, USA.
James M MusserCenter for Molecular and Translational Human Infectious Disease Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.
Randall J OlsenCenter for Molecular and Translational Human Infectious Disease Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA rjolsen@houstonmethodist.org.
Houston Methodist · USTexas A&M Health Science Center · USThe University of Texas Health Science Center at Houston · US

Funding

Determinants of Streptococcus pyogenes virulence in the primate oropharynx: A genome-wide analysisR21AI139369 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI MUSSER, JAMES MALLORY · 2019 to 2020
$444k
Determinants of Streptococcus pyogenes fitness in the female primate genital tract: A genome-wide analysisR21AI146771 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI MUSSER, JAMES MALLORY · 2019 to 2020
$444k
NIAID NIH HHS R21 AI139369NIAID NIH HHS R21 AI146771
6 · The paper itself

Abstract

Group A

Indexed as

Amino Acid SequenceAmino Acid SubstitutionAnimalsBacterial ProteinsBinding SitesCloning, MolecularEscherichia coliFasciitis, NecrotizingFemaleGene ExpressionGene Expression Regulation, BacterialGenetic VectorsHistidine KinaseHumansMiceMutationBacterial ProteinsCovS protein, Streptococcus pyogenesCsrR protein, Streptococcus pyogenesHistidine KinaseRepressor ProteinsRocA protein, Streptococcus pyogenesTrans-Activatorsaccessory proteingroup A Streptococcusmolecular pathogenesisprotein-protein interactionsRocASCAMTM

Identifiers

PMID32817331
PMCPMC7573446
OpenAlexW3062037637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.