Evidence map›Paper›PMID 32817263›Full record

ArticleLife science alliance2020

DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis.

Nazia Abbasi, Tianyun Long, Yuxin Li, Brian A Yee, Benjamin S Cho, Juan E Hernandez, Evelyn Ma, Parth R Patel, Debashis Sahoo, Ibrahim M Sayed and 5 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Article
  10. Methylation-Regulated Long Non-Coding RNA Expression in Ulcerative Colitis.International journal of molecular sciences · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Nazia AbbasiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Tianyun LongDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Yuxin LiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Brian A YeeDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Benjamin S ChoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Juan E HernandezDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-9386-2616
Evelyn MaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Parth R PatelDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Debashis SahooDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Ibrahim M SayedDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Nissi VarkiDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Soumita DasDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Pradipta GhoshDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Wendy Jia Men HuangDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA wjh003@health.ucsd.edu.ORCID 0000-0001-7425-8280
University of California San Diego · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Functional RNA elements in the human genomeR01HG004659 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett, Eugene Wei-Ming Yeo · 2008 to 2026
$12.4M
A Comprehensive Functional Map of Human Protein-RNA InteractionsU41HG009889 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R., YEO, EUGENE WEI-MING · 2018 to 2021
$9.4M
Spatial Regulation of RGS and G Protein SignalingR01CA100768 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 2003 to 2019
$7.4M
Modulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal InflammationR01AI141630 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pradipta Ghosh · 2019 to 2026
$3.2M
Integrators of Metastatic PotentialR01CA238042 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA, LUKER, GARY D · 2019 to 2023
$2.3M
Innate responses following infection with enteric microbesR01DK107585 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2016 to 2020
$2.2M
Post-translational modifications in RORgt-dependent immune cell functionsR01GM124494 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUANG, WENDY JIA MEN · 2017 to 2021
$2.0M
Summer Student Research on the Application of Boolean AnalysisR01GM138385 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2020 to 2023
$2.0M
Network-Based Novel Therapeutics in Colorectal CancersUG3TR002968 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2019 to 2021
$946k
Precision therapeutics of inflammatory bowel disease guided by Boolean logicUG3TR003355 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2020 to 2022
$937k
Application of Boolean Networks to discover stem and progenitor cellsR00CA151673 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2014 to 2016
$717k
NCATS NIH HHS UG3 TR002968NCI NIH HHS P30 CA023100NCI NIH HHS R00 CA151673NHGRI NIH HHS R01 HG004659NHGRI NIH HHS U41 HG009889NIAID NIH HHS R01 AI141630NIDDK NIH HHS R01 DK107585NIGMS NIH HHS R01 GM124494NIGMS NIH HHS R01 GM138385NIH HHS S10 OD026929
6 · The paper itself

Abstract

Tumorigenesis in different segments of the intestinal tract involves tissue-specific oncogenic drivers. In the colon, complement component 3 (C3) activation is a major contributor to inflammation and malignancies. By contrast, tumorigenesis in the small intestine involves fatty acid-binding protein 1 (FABP1). However, little is known of the upstream mechanisms driving their expressions in different segments of the intestinal tract. Here, we report that the RNA-binding protein DDX5 binds to the mRNA transcripts of

Indexed as

AnimalsCarcinogenesisColitisComplement C3DEAD-box RNA HelicasesDextran SulfateEpithelial CellsFatty Acid-Binding ProteinsFemaleGene ExpressionGene Expression Regulation, NeoplasticInflammationIntestinal MucosaIntestinesIntestine, SmallMaleC3 protein, mouseComplement C3Ddx5 protein, mouseDEAD-box RNA HelicasesDextran SulfateFabp1 protein, mouseFatty Acid-Binding Proteins

Identifiers

PMID32817263
PMCPMC7441524
OpenAlexW3060959798

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.