Evidence map›Paper›PMID 32817222›Full record

ArticleJournal of virology2020

HIV-1 Lethality and Loss of Env Protein Expression Induced by Single Synonymous Substitutions in the Virus Genome Intronic-Splicing Silencer.

Ana Jordan-Paiz, Maria Nevot, Kevin Lamkiewicz, Marie Lataretu, Sandra Franco, Manja Marz, Miguel Angel Martinez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Jordan-PaizIrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Maria NevotIrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Kevin LamkiewiczRNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University, Jena, Germany.
Marie LataretuRNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University, Jena, Germany.
Sandra FrancoIrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Manja MarzRNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University, Jena, Germany.
Miguel Angel MartinezIrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain mmartinez@irsicaixa.es.ORCID 0000-0002-6681-4950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synonymous genome recoding has been widely used to study different aspects of virus biology. Codon usage affects the temporal regulation of viral gene expression. In this study, we performed synonymous codon mutagenesis to investigate whether codon usage affected HIV-1 Env protein expression and virus viability. We replaced the codons AGG, GAG, CCU, ACU, CUC, and GGG of the HIV-1

Indexed as

Genome, ViralSilent MutationBase PairingBase SequenceCD4-Positive T-LymphocytesCell LineCodonenv Gene Products, Human Immunodeficiency VirusExonsHEK293 CellsHIV-1HumansIntronsRNA FoldingRNA SplicingStructure-Activity RelationshipCodonenv Gene Products, Human Immunodeficiency Virusenvelopehuman immunodeficiency viruslethalitysynonymous substitutions

Identifiers

PMID32817222
PMCPMC7565636

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.