ArticleNeurology2020
Association of specific biotypes in patients with Parkinson disease and disease progression.
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Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 38 citations in OpenAlex.
- Spatiotemporal Progression Patterns of Striatal Dopamine Depletion and Cerebral Hypoperfusion in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Identifing two distinct cortical progression subtypes of Parkinson's disease through multimodal neuroimaging.European journal of nuclear medicine and molecular imaging · 2026Article
- A Canonical Neural Map and Its Deviations Shape Parkinson's Disease Phenotypes.Research square · 2026Article
- Data-driven subtyping of Parkinson's disease using MRI: current insights, challenges, and future directions.Frontiers in aging neuroscience · 2026Review
- Diagnostic utility of biomarkers in progressive supranuclear palsy: toward a biotyping framework.Journal of neurology · 2025Review
- Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Atlas of Proteomic signatures of brain structure and its links to brain disorders.Nature communications · 2025Article
- Moving toward precision and personalized treatment strategies in psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Analysis of Two Neuroanatomical Subtypes of Parkinson's Disease and Their Motor Progression Based on Semi-Supervised Machine Learning.CNS neuroscience & therapeutics · 2025Article
- MRI subtypes in Parkinson's disease across diverse populations and clustering approaches.NPJ Parkinson's disease · 2024Article
- Pain in Parkinson's disease: a neuroanatomy-based approach.Brain communications · 2024Review
- Identification of Parkinson's disease subtypes with distinct brain atrophy progression and its association with clinical progression.Psychoradiology · 2024Article
- Two distinct trajectories of clinical and neurodegeneration events in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Behavioral and biologic characteristics of cancer-related cognitive impairment biotypes.Brain imaging and behavior · 2023Article
- Artificial intelligence-based clustering and characterization of Parkinson's disease trajectories.Scientific reports · 2023Article
- Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies.Frontiers in neuroscience · 2023Review
- Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment.Frontiers in medicine · 2023Review
- The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study.Frontiers in neurology · 2023Article
- Magnetic Resonance Imaging Studies of Neurodegenerative Disease: From Methods to Translational Research.Neuroscience bulletin · 2023Review
- Deep phenotyping for precision medicine in Parkinson's disease.Disease models & mechanisms · 2022Article
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Authors and funding
12 authors at 1 institution in 3 countries.
Linbo WangFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK.ORCID 0000-0002-6982-103X
Wei ChengFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK. jffeng@fudan.edu.cn peter.brown@ndcn.ox.ac.uk wcheng.fdu@gmail.com.
Edmund T RollsFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK.ORCID 0000-0003-3025-1292
Fuli DaiFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK.
Weikang GongFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK.
Jingnan DuFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK.
Wei ZhangFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK.
Shouyan WangFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK.ORCID 0000-0002-9776-8539
Fengtao LiuFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK.ORCID 0000-0001-5194-6814
Jian WangFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK.
Peter BrownFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK. jffeng@fudan.edu.cn peter.brown@ndcn.ox.ac.uk wcheng.fdu@gmail.com.
Jianfeng FengFrom the Institute of Science and Technology for Brain-inspired Intelligence (L.W., W.C., E.R., F.D, W.G., J. D., W.Z., S.W., J.F.), Fudan University; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (L.W., W.C., J. D., W.Z., S.W., J.F.) (Fudan University), Ministry of Education, Shanghai, China; Department of Computer Science (E.R., J.F.), University of Warwick, Coventry; Oxford Centre for Computational Neuroscience (E.R.), UK; Department of Neurology and National Clinical Research Center for Aging and Medicine (F.L., J.W.), Huashan Hospital, Fudan University, Shanghai, China; and Medical Research Council Brain Network Dynamics Unit (P.B.) and Nuffield Department of Clinical Neurosciences (P.B.), University of Oxford, UK. jffeng@fudan.edu.cn peter.brown@ndcn.ox.ac.uk wcheng.fdu@gmail.com.
Fudan University · CN
Funding
Department of HealthMedical Research Council MC_UU_00003/2Medical Research Council MC_UU_12024/1
Abstract
objectiveTo identify biotypes in patients with newly diagnosed Parkinson disease (PD) and to test whether these biotypes could explain interindividual differences in longitudinal progression.
methodsIn this longitudinal analysis, we use a data-driven approach clustering PD patients from the Parkinson's Progression Markers Initiative (n = 314, age 61.0 ± 9.5, years 34.1% female, 5 years of follow-up). Voxel-level neuroanatomic features were estimated with deformation-based morphometry (DBM) of T1-weighted MRI. Voxels with deformation values that were significantly correlated (
resultsTwo neuroanatomic biotypes were identified: biotype 1 (n = 114) with subcortical brain volumes smaller than heathy controls and biotype 2 (n = 200) with subcortical brain volumes larger than heathy controls. Biotype 1 had more severe motor impairment, autonomic dysfunction, and much worse REM sleep behavior disorder than biotype 2 at baseline. Although disease durations at the initial visit and follow-up were similar between biotypes, patients with PD with smaller subcortical brain volume had poorer prognosis, with more rapid decline in several clinical domains and in dopamine functional neuroimaging over an average of 5 years.
conclusionRobust neuroanatomic biotypes exist in PD with distinct clinical and neuroanatomic patterns. These biotypes can be detected at diagnosis and predict the course of longitudinal progression, which should benefit trial design and evaluation.
Indexed as
Disease ProgressionAgedCluster AnalysisFemaleHumansLongitudinal StudiesMaleMiddle AgedParkinson DiseasePositron-Emission TomographyTomography, X-Ray Computed
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