Evidence map›Paper›PMID 32817125›Full record

ArticleThe Journal of biological chemistry2020

Finding proteases that make cells go viral.

Hector C Aguilar, David W Buchholz

Open access · hybridAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hector C AguilarDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA ha363@cornell.edu.
David W BuchholzDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
New York State College of Veterinary Medicine · US

Funding

Mechanisms of Nipah virus fusion and entryR01AI109022 · NIAID · WASHINGTON STATE UNIVERSITY · PI AGUILAR-CARRENO, HECTOR · 2014 to 2024
$4.3M
Immuno-Engineering: Integrated Engineering and Immunology TrainingT32EB023860 · NIBIB · CORNELL UNIVERSITY · PI AUGUST, AVERY, PUTNAM, DAVID A · 2018 to 2022
$933k
Identifying potent and broadly-neutralizing henipaviral antigens and epitopesR21AI142377 · NIAID · CORNELL UNIVERSITY · PI AGUILAR-CARRENO, HECTOR · 2019 to 2020
$416k
NIAID NIH HHS R01 AI109022NIAID NIH HHS R21 AI142377NIBIB NIH HHS T32 EB023860
6 · The paper itself

Abstract

The activation of influenza virus hemagglutinin (HA) glycoprotein via cleavage by host cell proteases is essential for viral infectivity, and understanding the mechanisms for HA protein cleavage and how they may differ depending on the biological context is important for the development of flu treatments. However, the HA proteases involved in the activation of many viral strains remain unidentified. In this issue, Harbig

Indexed as

Influenza B virusInfluenza, HumanAnimalsGene Expression ProfilingHemagglutinin Glycoproteins, Influenza VirusInfluenza A Virus, H3N2 SubtypeMicePeptide HydrolasesHemagglutinin Glycoproteins, Influenza VirusPeptide Hydrolases

Identifiers

PMID32817125
PMCPMC7450131
OpenAlexW3049732142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.