ArticlemBio2020
A Plant Virus Ensures Viral Stability in the Hemolymph of Vector Insects through Suppressing Prophenoloxidase Activation.
Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular and Functional Characterization of Black Soldier Fly Derived Peptide Against Food-Relevant Bacteria.Foods (Basel, Switzerland) · 2026Article
- A Plant Virus Glycoprotein Induces Autophagy by Activating the Toll7 Immune Pathway in Its Insect Vector.Molecular plant pathology · 2026Article
- Purα is an essential host factor for rice stripe virus accumulation and transmission in the small brown planthopper.Archives of virology · 2026Article
- RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Insect I-Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- A plant virus attenuates the Toll immune pathway by degradation of Pellino to facilitate viral infection in insect vectors.Journal of virology · 2025Article
- A phytoplasma effector suppresses insect melanization immune response to promote pathogen persistent transmission.Science advances · 2025Article
- Small interfering RNAs generated from the terminal panhandle structure of negative-strand RNA virus promote viral infection.PLoS pathogens · 2025Article
- Effects of synergistic fermentation of tea bee pollen with bacteria and enzymes on growth and intestinal health ofCurrent research in microbial sciences · 2025Article
- Maintenance of persistent transmission of a plant arbovirus in its insect vector mediated by the Toll-Dorsal immune pathway.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- MicroRNA Targets PAP1 to Mediate Melanization inInternational journal of molecular sciences · 2024Article
- Immune Responses and Transcriptomic Analysis ofPlants (Basel, Switzerland) · 2023Article
- Article
- Key role of exportin 6 in exosome-mediated viral transmission from insect vectors to plants.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication.Protein & cell · 2022Article
- Flotillin 2 Facilitates the Infection of a Plant Virus in the Gut of Insect Vector.Journal of virology · 2022Article
- Heat shock cognate protein 70 is required for rice stripe tenuivirus accumulation and transmission in small brown planthopper.Archives of virology · 2022Article
- Alternative Splicing Landscape of Small Brown Planthopper and Different Response of JNK2 Isoforms to Rice Stripe Virus Infection.Journal of virology · 2022Article
- Nucleoprotein of a Rice Rhabdovirus Serves as the Effector to Attenuate Hemolymph Melanization and Facilitate Viral Persistent Propagation in its Leafhopper Vector.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most plant viruses require vector insects for transmission. Viral stability in the hemolymph of vector insects is a prerequisite for successful transmission of persistent plant viruses. However, knowledge of whether the proteolytic activation of prophenoloxidase (PPO) affects the stability of persistent plant viruses remains elusive. Here, we explored the interplay between rice stripe virus (RSV) and the PPO cascade of the vector small brown planthopper. Phenoloxidase (PO) activity was suppressed by RSV by approximately 60%. When the PPO cascade was activated, we found distinct melanization around RSV particles and serious damage to viral stability in the hemolymph. Viral suppression of PO activity was derived from obstruction of proteolytic cleavage of PPOs by binding of the viral nonstructural protein NS3. These results indicate that RSV attenuates the PPO response to ensure viral stability in the hemolymph of vector insects. Our research provides enlightening cues for controlling the transmission of vector-borne viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.