Evidence map›Paper›PMID 32816996›Full record

ArticleDiabetes care2020

Sex Differences in Coronary Artery Calcium and Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in Adults With Diabetes: The Coronary Calcium Consortium.

Nathan D Wong, Amber R Cordola Hsu, Alan Rozanski, Leslee J Shaw, Seamus P Whelton, Matthew J Budoff, Khurram Nasir, Michael D Miedema, John Rumberger, Michael J Blaha and 1 more

Abstract read
In one paragraph

Article in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  15. Long-term outcomes of lung cancer screening in males and females.Lung cancer (Amsterdam, Netherlands) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nathan D WongHeart Disease Prevention Program, Division of Cardiology, University of California, Irvine, Irvine, CA.ORCID 0000-0003-1102-7324
Amber R Cordola HsuHeart Disease Prevention Program, Division of Cardiology, University of California, Irvine, Irvine, CA.
Alan RozanskiDivision of Cardiology, Mount Sinai Morningside, New York, NY.
Leslee J ShawDepartment of Radiology, Cornell University, New York, NY.
Seamus P WheltonDivision of Cardiology, Ciccarone Center for the Prevention of Cardiovascular Disease, John Hopkins University, Baltimore, MD.ORCID 0000-0001-5914-0735
Matthew J BudoffLindquist Institute, Torrance, CA.
Khurram NasirDivision of Cardiology, Baylor College of Medicine, Houston, TX.
Michael D MiedemaCardiovascular Prevention, Minneapolis Heart Institute and Foundation, Minneapolis, MN.
John RumbergerPrinceton Longevity Center, Princeton, NJ.
Michael J BlahaDivision of Cardiology, Ciccarone Center for the Prevention of Cardiovascular Disease, John Hopkins University, Baltimore, MD.ORCID 0000-0001-5138-9683
Daniel S BermanDepartment of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA bermand@cshs.org.ORCID 0000-0002-3793-9578

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWhile diabetes has been previously noted to be a stronger risk factor for cardiovascular disease (CVD) in women compared with men, whether this is still the case is not clear. Coronary artery calcium (CAC) predicts coronary heart disease (CHD) and CVD in people with diabetes; however, its sex-specific impact is less defined. We compared the relation of CAC in women versus men with diabetes for total, CVD, and CHD mortality. RESEARCH DESIGN AND

methodsWe studied adults with diabetes from a large registry of patients with CAC scanning with mortality follow-up over 11.5 years. Cox regression examined the relation of CAC with mortality end points.

resultsAmong 4,503 adults with diabetes (32.5% women) aged 21-93 years, 61.2% of women and 80.4% of men had CAC >0. Total, CVD, and CHD mortality rates were directly related to CAC; women had higher total and CVD death rates than men when CAC >100. Age- and risk factor-adjusted hazard ratios (HRs) per log unit CAC were higher among women versus men for total mortality (1.28 vs. 1.18) (interaction

conclusionsCAC predicts CHD, CVD, and all-cause mortality in patients with diabetes; however, greater CAC predicts CVD and total mortality more strongly in women.

Indexed as

AdultAgedAged, 80 and overCalciumCardiovascular DiseasesCause of DeathCoronary Artery DiseaseDiabetes MellitusDiabetic AngiopathiesFemaleHumansMaleMiddle AgedMortalityRisk AssessmentRisk FactorsCalcium

Identifiers

PMID32816996
PMCPMC8051260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.