ArticleCancer research2020
Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies.
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Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.Genes & diseases · 2026Review
- Evaluating statistical models for overdispersed multiomics data: a multiplex immunofluorescence case study.American journal of epidemiology · 2026Article
- Alcohol consumption and molecular subtypes of colorectal cancer: pooled observational and Mendelian randomization analyses.The American journal of clinical nutrition · 2026Observational
- Saskatoon berry (Food science and biotechnology · 2026Review
- Improving dietary fiber intake is associated with a declining burden of early-onset colorectal cancer: a three-decade comparative analysis in China and globally.International journal of colorectal disease · 2026Article
- Density of T-cell Subsets in Colorectal Cancer in Relation to Disease-Specific Survival.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Deciphering the impact of dietary habits and behavioral patterns on colorectal cancer.International journal of surgery (London, England) · 2025Review
- Prevalence and antibiotic resistance of Escherichia coli in urban and peri-urban garden ecosystems in Bangladesh.PloS one · 2025Article
- Interplay Between Dietary Phytochemicals and Gut Microbiota in Colorectal Cancer: Future Directions and Considerations.Journal of nutrition and metabolism · 2025Review
- The additive interaction of healthy lifestyles and genetic susceptibility on colorectal cancer risk in prediabetes: a large population-based prospective cohort study.BMC gastroenterology · 2024Article
- Genetically predicted dietary intake and risks of colorectal cancer: a Mendelian randomisation study.BMC cancer · 2024Article
- Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.The American journal of clinical nutrition · 2024Article
- Fruit but not vegetable consumption is beneficial for low prevalence of colorectal polyps in a high-risk population: findings from a Chinese Lanxi Pre-colorectal Cancer Cohort study.European journal of nutrition · 2024Article
- Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Dietary fiber influence on overall health, with an emphasis on CVD, diabetes, obesity, colon cancer, and inflammation.Frontiers in nutrition · 2024Review
- Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors.Frontiers in immunology · 2024Article
- Genome-wide interaction analysis of folate for colorectal cancer risk.The American journal of clinical nutrition · 2023Article
- Sugar intake and colorectal cancer risk: A prospective Japanese cohort study.Cancer science · 2023Article
- Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases.Journal of gastroenterology · 2023Article
- Body mass index and molecular subtypes of colorectal cancer.Journal of the National Cancer Institute · 2023Article
Corrections and comments
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Authors and funding
42 authors at 20 institutions in 7 countries.
Akihisa HidakaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. akihisahidaka@gmail.com.ORCID 0000-0002-1772-8159
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-4173-7530
Yin CaoDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-0900-5735
Richard BarfieldPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Marios GiannakisDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Mingyang SongDepartments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Amanda I PhippsPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Syed H ZaidiOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Amanda E TolandDepartments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Efrat L AmitayDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8585-7622
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Ivan BorozanOntario Institute for Cancer Research, Toronto, Canada.
Andrew T ChanClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Steven GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Marc J GunterNutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Mark A GuinterBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.ORCID 0000-0001-5547-7795
Sophia HarlidDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.ORCID 0000-0001-8540-6891
Heather HampelDepartments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.ORCID 0000-0001-7558-9794
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Victor MorenoOncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0002-2818-5487
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Reiko NishiharaProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Shuji OginoBroad Institute of Harvard and MIT, Cambridge, Massachusetts.ORCID 0000-0002-3909-2323
Mireia Obón-SantacanaOncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Patrick S ParfreyMemorial University, Faculty of Medicine, Newfoundland, Canada.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0001-5439-1500
Martha L SlatteryDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0002-1655-6543
Robert S SteinfelderPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Caroline Y UmBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.ORCID 0000-0001-5449-6230
Xiaoliang WangPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Michael O WoodsMemorial University of Newfoundland, Discipline of Genetics, St. John's, Canada.
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.ORCID 0000-0002-9692-101X
Stephen N ThibodeauDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8307-3197
Wei SunPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-6350-1107
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Daniel D BuchananUniversity of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.ORCID 0000-0003-2225-6675
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Fred Hutch Cancer Center · USUniversity of Washington · USAmerican Cancer Society · USBellvitge University Hospital · ESBroad Institute · USGerman Cancer Research Center · DEMemorial University of Newfoundland · CAOntario Institute for Cancer Research · CAThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USUmeå University · SEBrigham and Women's Hospital · USCentre international de recherche sur le cancer · FRDana-Farber Cancer Institute · USHarvard University · USKaiser Permanente · USLunenfeld-Tanenbaum Research Institute · CAMayo Clinic · USNational Cancer Institute · USThe Royal Melbourne Hospital · AUThe University of Melbourne · AU
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FUCHS, CHARLES S · 1991 to 2009
$41.8MTissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI EL-BARDEESY, NABEEL, SELLERS, WILLIAM R · 2007 to 2023
$33.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MCancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5MDetection of Colorectal Cancer Susceptibility Loci Using Genome-Wide SequencingU01CA164930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2012 to 2015
$12.4MNCI NIH HHS K07 CA190673NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA016058NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA201407NCI NIH HHS R21 CA191312NCI NIH HHS R35 CA197735NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA167552NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008IWorld Health Organization 001
Abstract
Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all epidemiologic studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by colorectal cancer molecular subtypes. Here, we investigate the association of fruit, vegetables, and fiber intake with four well-established colorectal cancer molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in
Indexed as
FruitVegetablesCase-Control StudiesColorectal NeoplasmsCpG IslandsDietary FiberDNA MethylationFemaleHumansMaleMicrosatellite InstabilityProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Risk FactorsBRAF protein, humanDietary FiberKRAS protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)
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