Evidence map›Paper›PMID 32816768›Full record

ReviewAJNR. American journal of neuroradiology2020

Neuroimaging Advances in Deep Brain Stimulation: Review of Indications, Anatomy, and Brain Connectomics.

E H Middlebrooks, R A Domingo, T Vivas-Buitrago, L Okromelidze, T Tsuboi, J K Wong, R S Eisinger, L Almeida, M R Burns, A Horn and 4 more

Open access · hybridAbstract readReview
In one paragraph

Review in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Preoperative network activity predicts the response to subthalamic DBS for Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  18. Biomarkers for Epilepsy Deep Brain Stimulation.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025
    Review
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

E H MiddlebrooksFrom the Departments of Radiology (E.H.M., L.O.) middlebrooks.erik@mayo.edu.ORCID 0000-0002-4418-9605
R A DomingoNeurosurgery (E.H.M., R.A.D., T.V.-B., R.E.W., S.S.G.).ORCID 0000-0002-8950-1762
T Vivas-BuitragoNeurosurgery (E.H.M., R.A.D., T.V.-B., R.E.W., S.S.G.).ORCID 0000-0002-1096-3471
L OkromelidzeFrom the Departments of Radiology (E.H.M., L.O.).ORCID 0000-0002-1296-0522
T Tsuboiand Neurology (R.J.U.), Mayo Clinic, Jacksonville, Florida.ORCID 0000-0001-5042-3181
J K Wongand Neurology (R.J.U.), Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-4632-3417
R S Eisingerand Neurology (R.J.U.), Mayo Clinic, Jacksonville, Florida.ORCID 0000-0003-3191-2355
L Almeidaand Neurology (R.J.U.), Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-0921-887X
M R Burnsand Neurology (R.J.U.), Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-9309-7723
A HornDepartment of Neurology (T.T.), Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-0695-6025
R J UittiDepartment for Neurology (A.H.), Charité, University Medicine Berlin, Berlin, Germany.ORCID 0000-0001-8113-4710
R E WharenNeurosurgery (E.H.M., R.A.D., T.V.-B., R.E.W., S.S.G.).ORCID 0000-0002-9064-6563
V M HolandaCenter of Neurology and Neurosurgery Associates (V.M.H.), BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.ORCID 0000-0002-5600-2916
S S GrewalNeurosurgery (E.H.M., R.A.D., T.V.-B., R.E.W., S.S.G.).ORCID 0000-0002-4307-7062
Jacksonville College · USHesco (United States) · USBeneficência Portuguesa de São Paulo · BRMayo Clinic in Arizona · USMayo Clinic in Florida · USNagoya University · JPNeurology, Inc · US

Funding

University of Florida R25 Early Research Program for Neurology and Neurosurgery ResidentsR25NS108939 · NINDS · UNIVERSITY OF FLORIDA · PI HOH, BRIAN LIM, HOH, BRIAN LIM · 2019 to 2024
$537k
Local field potentials reveal reward processing and impulse control disorders in Parkinson’s diseaseF30NS111841 · NINDS · UNIVERSITY OF FLORIDA · PI EISINGER, ROBERT STEPHEN · 2019 to 2022
$124k
NINDS NIH HHS F30 NS111841NINDS NIH HHS R25 NS108939
6 · The paper itself

Abstract

Deep brain stimulation is an established therapy for multiple brain disorders, with rapidly expanding potential indications. Neuroimaging has advanced the field of deep brain stimulation through improvements in delineation of anatomy, and, more recently, application of brain connectomics. Older lesion-derived, localizationist theories of these conditions have evolved to newer, network-based "circuitopathies," aided by the ability to directly assess these brain circuits in vivo through the use of advanced neuroimaging techniques, such as diffusion tractography and fMRI. In this review, we use a combination of ultra-high-field MR imaging and diffusion tractography to highlight relevant anatomy for the currently approved indications for deep brain stimulation in the United States: essential tremor, Parkinson disease, drug-resistant epilepsy, dystonia, and obsessive-compulsive disorder. We also review the literature regarding the use of fMRI and diffusion tractography in understanding the role of deep brain stimulation in these disorders, as well as their potential use in both surgical targeting and device programming.

Indexed as

BrainConnectomeDeep Brain StimulationDiffusion Tensor ImagingHumans

Identifiers

PMID32816768
PMCPMC7583111
OpenAlexW3049507753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.