Evidence map›Paper›PMID 32816747›Full record

ArticleBMJ (Clinical research ed.)2020

Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study.

Gitte J Holst, Carsten B Pedersen, Malene Thygesen, Jørgen Brandt, Camilla Geels, Jakob H Bønløkke, Torben Sigsgaard

Abstract read
In one paragraph

Article in BMJ (Clinical research ed.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Association of PMRespiratory research · 2026
    Article
  9. Most respiratory symptoms have resolved 9 years after PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026
    Article
  10. Article
  11. Review
  12. Exposure to daily mean and maximum 1-hour PMEnvironmental epidemiology (Philadelphia, Pa.) · 2025
    Article
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Perspectives on environment and health research in Denmark.Scandinavian journal of public health · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Gitte J HolstDepartment of Public Health, Section of Environment, Occupation and Health, Aarhus University, Bartholin Allé 2, 8000 Aarhus C, Denmark.ORCID 0000-0001-5717-099X
Carsten B PedersenNational Centre for Register-Based Research, School of Business and Social Sciences, Aarhus University, Denmark.
Malene ThygesenNational Centre for Register-Based Research, School of Business and Social Sciences, Aarhus University, Denmark.
Jørgen BrandtDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Camilla GeelsDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Jakob H BønløkkeDepartment of Occupational and Environmental Medicine, Danish Ramazzini Centre, Aalborg University Hospital, Aalborg, Denmark.
Torben SigsgaardDepartment of Public Health, Section of Environment, Occupation and Health, Aarhus University, Bartholin Allé 2, 8000 Aarhus C, Denmark ts@ph.au.dk.ORCID 0000-0002-2043-7571

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify risk factors (air pollution and family related) for the onset of asthma and persistent wheezing in children.

designNationwide case-control study.

settingDenmark.

participantsAll Danish children born from 1997 to 2014 and followed for asthma onset and persistent wheezing from age 1 year to 15 years.

main outcome measureOnset of asthma and persistent wheezing.

resultsA higher incidence of asthma was found in children of parents with asthma (adjusted hazard ratio 2.29 (95% confidence interval 2.22 to 2.35) and mothers who smoked during pregnancy (1.20, 1.18 to 1.22), whereas a lower incidence was found in children of parents with high educational attainment (0.72, 0.69 to 0.75) and high incomes (0.85, 0.81 to 0.89). Exposure to particulate matter ≤2.5 µm (PM

conclusionsThe findings of this study suggest that children exposed to higher levels of PM

Indexed as

Respiratory SoundsAdolescentAir PollutantsAsthmaCase-Control StudiesChildChild, PreschoolDenmarkEducational StatusFemaleHumansIncidenceInfantMaleNitratesNitrogen DioxideAir PollutantsNitratesNitrogen DioxideParticulate Matter

Identifiers

PMID32816747
PMCPMC7437497

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.