Evidence map›Paper›PMID 32816606›Full record

ArticleRNA biology2021

Adel B Alharbi, Ulf Schmitz, Amy D Marshall, Darya Vanichkina, Rajini Nagarajah, Melissa Vellozzi, Justin Jl Wong, Charles G Bailey, John Ej Rasko

Abstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. An updated catalog ofFrontiers in molecular neuroscience · 2023
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. A cohesin traffic pattern genetically linked to gene regulation.Nature structural & molecular biology · 2022
    Article
  9. 3D chromatin remodeling potentiates transcriptional programs driving cell invasion.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. CTCF: A misguided jack-of-all-trades in cancer cells.Computational and structural biotechnology journal · 2022
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adel B AlharbiGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney , Camperdown, Australia.ORCID 0000-0002-9644-1032
Ulf SchmitzGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney , Camperdown, Australia.
Amy D MarshallGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney , Camperdown, Australia.
Darya VanichkinaGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney , Camperdown, Australia.ORCID 0000-0002-0406-164X
Rajini NagarajahGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney , Camperdown, Australia.
Melissa VellozziGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney , Camperdown, Australia.
Justin Jl WongFaculty of Medicine and Health, The University of Sydney , Camperdown, Australia.ORCID 0000-0002-7038-5079
Charles G BaileyGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney , Camperdown, Australia.
John Ej RaskoGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney , Camperdown, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CTCF is a master regulator of gene transcription and chromatin organisation with occupancy at thousands of DNA target sites genome-wide. While CTCF is essential for cell survival, CTCF haploinsufficiency is associated with tumour development and hypermethylation. Increasing evidence demonstrates CTCF as a key player in several mechanisms regulating alternative splicing (AS), however, the genome-wide impact of

Indexed as

Alternative SplicingGene Expression RegulationHaploinsufficiencyIntronsAnimalsBinding SitesCCCTC-Binding FactorGenotypeMiceMice, KnockoutModels, BiologicalOrgan SpecificityProtein BindingTranscriptomeCCCTC-Binding FactorCtcf protein, mouseAlternative splicingCTCF; exon skippinggene expressionhaploinsufficiencyintron retention

Identifiers

PMID32816606
PMCPMC7834090

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.