Evidence map›Paper›PMID 32816249›Full record

ArticleInfection2020

Renal profile of chronic hepatitis C patients with sofosbuvir-based therapy.

Mohammad El-Sayed, Zeinab Abdellatif, Aisha Elsharkawy, Mohamed El Kassas, Reham Abd Elmoniem, Amaal Marzouk, Rabab Fouad, Gamal Esmat, Shereen Abdel Alem

Abstract read
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In one paragraph

Article in Infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Renal Manifestations of Chronic Hepatitis C: A Review.Journal of clinical medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammad El-SayedEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt.
Zeinab AbdellatifEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt.
Aisha ElsharkawyEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt.
Mohamed El KassasEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Reham Abd ElmoniemEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt.
Amaal MarzoukEndemic Medicine Department, Abbassia Fever Hospital, Ministry of Health and Population, Cairo, Egypt.
Rabab FouadEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt.
Gamal EsmatEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt.
Shereen Abdel AlemEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt. shery_2424@yahoo.com.ORCID http://orcid.org/0000-0002-3612-0130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe impact of SOF-based therapy on renal functions is quite controversial in clinical practice. Therefore, we aimed to evaluate the serial changes of renal indices during SOF-based therapy in CHC patients with normal kidney function or mild renal impairment.

methodsWe retrospectively reviewed all CHC patients who received different SOF-based regimens from January 2015 until December 2017, and presented with a baseline eGFR ≥ 30 ml/min/1.73m

resultsA total of 1004 patients were finally included. The mean serum creatinine and eGFR levels varied between 0.84 mg/dl and 106.53 ml/min/1.73m

conclusionSOF-based therapies seem to be safe in CHC patients with baseline normal or slightly impaired renal function.

Indexed as

Glomerular Filtration RateAdultAgedAged, 80 and overAntiviral AgentsEgyptFemaleHepatitis C, ChronicHumansKidneyMaleMiddle AgedRenal InsufficiencyRetrospective StudiesSofosbuvirYoung AdultAntiviral AgentsSofosbuvirEstimated glomerular filtrationHepatitis C virusNormal renal functionsSofosbuvir-based treatmentSustained virological response

Identifiers

PMID32816249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.