SynthesisEuropean journal of epidemiology2020
Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis.
Synthesis in European journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
194 citing papers in PubMed, 4 syntheses or guidelines pooled it, 379 citations in OpenAlex.
- Significant association between anemia and higher risk for COVID-19 mortality: A meta-analysis of adjusted effect estimates.The American journal of emergency medicine · 2022Pooled it
- Iron dysregulation in COVID-19 and reciprocal evolution of SARS-CoV-2: Natura nihil frustra facit.Journal of cellular biochemistry · 2022Pooled it
- Red Blood Cell Distribution Is a Significant Predictor of Severe Illness in Coronavirus Disease 2019.Acta haematologica · 2021Pooled it
- Pooled it
- Trial
- Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial.Advances in experimental medicine and biology · 2023Trial
- Hypoglycemia and altered bile acid metabolism are linked to latent iron deficiency in young Japanese women.Journal of clinical biochemistry and nutrition · 2026Article
- High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2-induced prothrombotic state.Acta neuropathologica · 2026Article
- Association of Previous COVID-19 Infection and Preoperative Haemoglobin with Transfusion Burden and Early Postoperative Outcomes Following Cardiac Surgery with Cardiopulmonary Bypass.Journal of clinical medicine · 2026Article
- Article
- Illness trajectory in the longer term after hospitalisation for COVID-19: a prospective, multicentre cohort study.BMC infectious diseases · 2026Observational
- COVID-19-Related Hematological Abnormalities Among Adults; A Cross-Sectional Study in a Resource-Limited Setting.Immunity, inflammation and disease · 2026Article
- Kidney involvement and anemia in COVID-19 infection.World journal of nephrology · 2025Review
- Long-term clinical sequelae in severe fever with thrombocytopenia syndrome: A longitudinal cohort study.PLoS neglected tropical diseases · 2025Article
- Effect of COVID-19 on hematological parameters and subsequent risk of anemia and bleeding in middle-aged and elderly patients with type 2 diabetes.Journal of family medicine and primary care · 2025Article
- Exploring the role of mitochondrial dysfunction and aging in COVID-19-Related neurological complications.Molecular biology reports · 2025Review
- A cross-sectional study of laboratory parameters 5-6 months after the first COVID-19 infection.Heliyon · 2025Article
- Impact of SARS-CoV-2 Infection on Erythropoietin Resistance Index in Hemodialysis Patients.Geriatrics (Basel, Switzerland) · 2025Article
- Relationship Between Anemia and Telogen Effluvium in Post-COVID-19 Survivors.Dermatology practical & conceptual · 2025Article
- Haematological Manifestations of SARS-CoV-2: Insights into Erythropoiesis, Hepcidin Regulation, and Cytokine Storm.International journal of molecular sciences · 2025Review
134 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and erythrocyte indices) in patients diagnosed with COVID-19, and explored their prognostic value. Six bibliographic databases were searched up to August 3rd 2020. We included 189 unique studies, with data from 57,563 COVID-19 patients. Pooled mean hemoglobin and ferritin levels in COVID-19 patients across all ages were 129.7 g/L (95% Confidence Interval (CI), 128.51; 130.88) and 777.33 ng/mL (95% CI, 701.33; 852.77), respectively. Hemoglobin levels were lower with older age, higher percentage of subjects with diabetes, hypertension and overall comorbidities, and admitted to intensive care. Ferritin level increased with older age, increasing proportion of hypertensive study participants, and increasing proportion of mortality. Compared to moderate cases, severe COVID-19 cases had lower hemoglobin [weighted mean difference (WMD), - 4.08 g/L (95% CI - 5.12; - 3.05)] and red blood cell count [WMD, - 0.16 × 10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.