ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2020
Quality of life in a real-world cohort of advanced breast cancer patients: a study of the SONABRE Registry.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03577197 (Southeast Netherlands Advanced Breast Cancer Registry), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Southeast Netherlands Advanced Breast Cancer Registry
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychosocial interventions and health-related quality of life in adults with incurable cancer: systematic review.BMJ supportive & palliative care · 2025Pooled it
- Intra-Arterial Therapies for Liver Metastatic Breast Cancer: A Systematic Review and Meta-Analysis.Cardiovascular and interventional radiology · 2021Pooled it
- Clinically Meaningful, Patient-Centered Endpoints for Real-World Evidence Generation in Breast Cancer: Perspectives from the Multidisciplinary TRIUMPH Initiative.Advances in therapy · 2026Article
- Handling missing values in patient-reported outcome data in the presence of intercurrent events.BMC medical research methodology · 2025Article
- Quality of Life in Breast Cancer Patients in Saudi Arabia: A Systematic Review.Breast cancer (Dove Medical Press) · 2025Review
- Quantifying bias due to missing data in quality of life surveys of advanced-stage cancer patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Disease landscape of advanced HER2-breast cancer patients by treatment line in three EU countries and USA.Future oncology (London, England) · 2024Article
- Dynamic changes in quality of life, psychological status, and body image in women who underwent a mastectomy as compared with breast reconstruction: an 8-year follow up.Breast cancer (Tokyo, Japan) · 2023Article
- Psychosocial Aspects of Living Long Term with Advanced Cancer and Ongoing Systemic Treatment: A Scoping Review.Cancers · 2022Article
- Assessing the Quality of Life in Breast Cancer Women: A Cross Sectional Descriptive Study.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Quality of life of women with breast cancer in a tertiary referral university hospital.Health and quality of life outcomes · 2022Article
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeWe aimed to evaluate quality of life (QoL) using the European Quality of Life Five-Dimensions questionnaire (EQ-5D-3L) in a real-world cohort of Dutch advanced breast cancer (ABC) patients. Secondary, we reported differences in QoL between subgroups of patients based on age, comorbidity, tumor-, and treatment characteristics, and assessed the association of duration of metastatic disease and time to death with QoL.
methodsABC patients who attended the outpatient clinic between October 2010 and May 2011 were asked to fill out the EQ-5D-3L questionnaire. Patient-, disease-, and treatment characteristics were obtained from the medical files. Health-utility scores were calculated. Subgroups were described and compared for utility scores by parametric and non-parametric methods.
resultsA total of 92 patients were included with a median utility score of 0.691 (Interquartile range [IQR] 0.244). Patients ≥ 65 years had significantly worse median utility scores than younger patients; 0.638 versus 0.743, respectively (p = 0.017). Moreover, scores were significantly worse for patients with versus those without comorbidity (medians 0.620 versus 0.725, p = 0.005). Utility scores did not significantly differ between subgroups of tumor type, type of systemic treatment, number of previous palliative treatment(s), or number or location of metastatic site(s). The remaining survival was correlated with utility scores (correlation coefficient (r) = 0.260, p = 0.0252), especially in the subgroup < 65 years (r = 0.340, p = 0.0169), whereas there was no significant correlation with time since metastatic diagnosis (r = - 0.106, p = 0.3136).
conclusionWithin this real-world cross-sectional study, QoL was significantly associated with age, comorbidity, and remaining survival duration. The observation of a lower QoL in ABC patients, possibly indicating the last period of life, may assist clinical decision-making on timing of cessation of systemic antitumor therapy.
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