Evidence map›Paper›PMID 32816194›Full record

ArticleCerebellum (London, England)2021

Cerebellar Grey Matter Volume in Older Persons Is Associated with Worse Cognitive Functioning.

A Buhrmann, A M A Brands, J van der Grond, C Schilder, R C van der Mast, N Rius Ottenheim, J C Foster-Dingley, A S Bertens, E van den Berg

Abstract read
PubMed Publisher
In one paragraph

Article in Cerebellum (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Consensus Paper: Cerebellum and Ageing.Cerebellum (London, England) · 2024
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

A BuhrmannDepartment of neuropsychiatry Vesalius, Altrecht Mental Health, Houttuinlaan 4, 3447 GM, Woerden, the Netherlands. abuhrmann@diakhuis.nl.ORCID http://orcid.org/0000-0002-7580-587X
A M A BrandsDepartment of Medical Psychology, Franciscus Gasthuis and Vlietland Hospital, Kleiweg 500, 3045 PM, Rotterdam, the Netherlands.
J van der GrondDepartment of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
C SchilderDepartment of Eating Disorders and Department of Psychodiagnostics, Altrecht Mental Health, Wenshoek 4, 3705, WE, Zeist, the Netherlands.
R C van der MastDepartment of Psychiatry, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
N Rius OttenheimDepartment of Psychiatry, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
J C Foster-DingleyDepartment of Psychiatry, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
A S BertensDepartment of Psychiatry, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
E van den BergDepartment of Neurology, Erasmus MC University Medical Centre, Dr. Molenwaterplein 40, 3015 GD, Rotterdam, the Netherlands.
Leiden University · NLAltrecht GGZ · NLErasmus MC · NLSint Franciscus Gasthuis · NL

Funding

ZonMw 40-41600-98-9014
6 · The paper itself

Abstract

The cerebellum is increasingly recognised for its role in modulation of cognition, behaviour, and affect. The present study examined the relation between structural cerebellar damage (grey matter volume (GMV), white matter hyperintensities (WMHs), lacunar infarcts (LIs) and microbleeds (MBs)) and measures of cognitive, psychological (i.e. symptoms of depression and apathy) and general daily functioning in a population of community-dwelling older persons with mild cognitive deficits, but without dementia. In 194 participants of the Discontinuation of Antihypertensive Treatment in Elderly People (DANTE) Study Leiden, the association between cerebellar GMV, WMHs, LIs and MBs and measures of cognitive, psychological and general daily functioning was analysed with linear regression analysis, adjusted for age, sex, education and cerebral volume. Cerebellar GMV was associated with the overall cognition score (standardised beta 0.20 [95% CI, 0.06-0.33]). Specifically, posterior cerebellar GMV was associated with executive function (standardised beta 0.18 [95% CI, 0.03-0.16]). No relation was found between vascular pathology and cognition. Also, no consistent associations were found on the cerebellar GMV and vascular pathology measures and psychological and general daily functioning. In this population of community-dwelling elderly, less posterior cerebellar GMV but not vascular pathology was associated with worse cognitive function, specifically with poorer executive function. No relation was found between cerebellar pathology and psychological and general daily functioning.

Indexed as

Activities of Daily LivingAgedAged, 80 and overBlood VesselsCerebellumCognitionCognition DisordersCognitive DysfunctionExecutive FunctionFemaleGray MatterHumansIndependent LivingMagnetic Resonance ImagingMaleMiddle AgedAffectCerebellumCognitionGeneral daily functionGrey matter volumeVascular

Identifiers

PMID32816194
OpenAlexW3076914972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.