Evidence map›Paper›PMID 32816152›Full record

ArticleClinical and experimental medicine2021

Overexpression of miR-27a predicts poor prognosis and promotes the progression in cholangiocarcinoma.

Yunxia Liu, Xia Liu, Yanhua Zhou, Tingting Liu, Jie Li

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical and experimental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yunxia LiuDepartment of Internal Medicine, Fuyanshan Branch of Affiliated Hospital of Weifang Medical University, Intersection of Limin Road and Fuyuan Street, Weifang, 261053, Shandong, China. liuyunxia3982@163.com.ORCID http://orcid.org/0000-0001-6640-7186
Xia LiuDepartment of Ophthalmology, Affiliated Hospital of Weifang Medical University, Weifang, 261031, Shandong, China.
Yanhua ZhouDepartment of Oncology, Affiliated Hospital of Weifang Medical University, Weifang, 261031, Shandong, China.
Tingting LiuDepartment of Internal Medicine, Fuyanshan Branch of Affiliated Hospital of Weifang Medical University, Intersection of Limin Road and Fuyuan Street, Weifang, 261053, Shandong, China.
Jie LiDepartment of Internal Medicine, Fuyanshan Branch of Affiliated Hospital of Weifang Medical University, Intersection of Limin Road and Fuyuan Street, Weifang, 261053, Shandong, China.
Weifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The function of microRNA-27a (miR-27a) expression in cholangiocarcinoma (CCA) remains largely unclear; therefore, this study aimed to investigate the clinical significance and functional role of miR-27a in CCA. This study included 117 paired CCA tissues and adjacent normal tissues from CCA patients who received surgical resection. Reverse transcription-quantitative polymerase chain reaction was used to measure the expression levels of miR-27a in CCA tissues and cell lines. A Kaplan-Meier curve and Cox regression analysis were used to determine overall prognostic performance. The effects of miR-27a on cell proliferation, migration, and invasion were measured by CCK-8 and Transwell assays. The expression levels of miR-27a in patients with CCA and cell lines were higher than those in adjacent normal tissues and normal cells, respectively. Additionally, miR-27a levels were found to be associated with lymph node metastasis and TNM stages. The overall survival time of CCA patients with high miR-27a expression was poorer than that of those with low miR-27a expression. Furthermore, miR-27a overexpression promoted CCA cell proliferation, migration, and invasion, whereas knockdown of miR-27a suppressed cell proliferation, migration, and invasion. Taken together, these results suggest the potential usefulness of miR-27a in the prognosis and progression of CCA.

Indexed as

Bile Duct NeoplasmsBiomarkers, TumorCell MovementCell ProliferationCholangiocarcinomaDisease ProgressionFemaleFollow-Up StudiesHumansMaleMicroRNAsMiddle AgedPrognosisSurvival RateTumor Cells, CulturedBiomarkers, TumorMicroRNAsMIRN27 microRNA, humanCholangiocarcinomaInvasionMicroRNA-27aMigrationPrognosisProliferation

Identifiers

PMID32816152
OpenAlexW3080082567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.