Evidence map›Paper›PMID 32816088›Full record

ArticleAnalytical and bioanalytical chemistry2021

Reduced graphene oxide-based field effect transistors for the detection of E7 protein of human papillomavirus in saliva.

Patrik Aspermair, Vladyslav Mishyn, Johannes Bintinger, Henri Happy, Komal Bagga, Palaniappan Subramanian, Wolfgang Knoll, Rabah Boukherroub, Sabine Szunerits

Open access · bronzeAbstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.

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  12. 2D Materials in Advanced Electronic Biosensors for Point-of-Care Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Patrik AspermairUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, 59000, Lille, France. Patrik.Aspermair@ait.ac.at.
Vladyslav MishynUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, 59000, Lille, France.
Johannes BintingerBiosensor Technologies, Austrian Institute of Technology, Konrad-Lorenz-Strasse 24, 3430, Tulln, Austria.
Henri HappyUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, 59000, Lille, France.
Komal BaggaAdvanced Processing Technology Research Centre, School of Mechanical and Manufacturing Engineering, Dublin City University, Glasnevin, Dublin 9, Ireland.
Palaniappan SubramanianDepartment of Materials Engineering, KU Leuven, Kateelpark Arenberg, 3001, Heverlee, Belgium.
Wolfgang KnollCEST Competence Centre for Electrochemical Surface Technologies, Konrad-Lorenz-Strasse 24, 3430, Tulln, Austria.
Rabah BoukherroubUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, 59000, Lille, France.
Sabine SzuneritsUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, 59000, Lille, France. sabine.szunerits@univ-lille.fr.
Centre National de la Recherche Scientifique · FRInstitut d'électronique de microélectronique et de nanotechnologie · FRAustrian Institute of Technology · ATDublin City University · IEKompetenzzentrum für elektrochemische Oberflächentechnologie · ATKU Leuven · BEUniversité Polytechnique Hauts-de-France · FR

Funding

H2020 Marie Skłodowska-Curie Actions 690836Österreichische Forschungsförderungsgesellschaft 870025
6 · The paper itself

Abstract

Several challenging biological sensing concepts have been realized using electrolyte-gated reduced graphene oxide field effect transistors (rGO-FETs). In this work, we demonstrate the interest of rGO-FET for the sensing of human papillomavirus (HPV), one of the most common sexually transmitted viruses and a necessary factor for cervical carcinogenesis. The highly sensitive and selective detection of the HPV-16 E7 protein relies on the attractive semiconducting characteristics of pyrene-modified rGO functionalized with RNA aptamer Sc5-c3. The aptamer-functionalized rGO-FET allows for monitoring the aptamer-HPV-16 E7 protein binding in real time with a detection limit of about 100 pg mL

Indexed as

Transistors, ElectronicAptamers, NucleotideBiosensing TechniquesElectrochemical TechniquesFeasibility StudiesGraphiteHuman papillomavirus 16HumansLimit of DetectionPapillomavirus E7 ProteinsPapillomavirus InfectionsSalivaSpectrum AnalysisTumor Virus InfectionsAptamers, Nucleotidegraphene oxideGraphiteoncogene protein E7, Human papillomavirus type 16Papillomavirus E7 ProteinsAptamerElectronic biosensorField effect transistorsHuman papillomavirus (HPV)Point-of-care diagnosticsReduced graphene oxide (rGO)Surface functionalization

Identifiers

PMID32816088
PMCPMC7438402
OpenAlexW3080653454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.