Evidence map›Paper›PMID 32815637›Full record

ArticleCancer medicine2020

EBV-LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer.

Kousho Wakae, Satoru Kondo, Hai Thanh Pham, Naohiro Wakisaka, Lusheng Que, Yingfang Li, Xin Zheng, Kento Fukano, Kouichi Kitamura, Koichi Watashi and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  10. CancerFrontiers in immunology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Kousho WakaeDepartment of Molecular Genetics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.ORCID 0000-0001-7767-6795
Satoru KondoDivision of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University, Kanazawa, Japan.
Hai Thanh PhamDivision of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University, Kanazawa, Japan.
Naohiro WakisakaDivision of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University, Kanazawa, Japan.
Lusheng QueDepartment of Molecular Genetics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Yingfang LiDepartment of Molecular Genetics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Xin ZhengDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Kento FukanoDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Kouichi KitamuraDepartment of Molecular Genetics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Koichi WatashiDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Hideki AizakiDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Takayoshi UenoDivision of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University, Kanazawa, Japan.
Makiko Moriyama-KitaDivision of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University, Kanazawa, Japan.
Kazuya IshikawaDivision of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University, Kanazawa, Japan.
Yosuke NakanishiDivision of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University, Kanazawa, Japan.
Kazuhira EndoDivision of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University, Kanazawa, Japan.
Masamichi MuramatsuDepartment of Molecular Genetics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Tomokazu YoshizakiDivision of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University, Kanazawa, Japan.
Kanazawa University · JPNational Institute of Infectious Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a principal oncogene that plays a pivotal role in EBV-associated malignant tumors including nasopharyngeal cancer (NPC). Recent genomic landscape studies revealed that NPC also contained many genomic mutations, suggesting the role of LMP1 as a driver gene for the induction of these genomic mutations. Nonetheless, its exact mechanism has not been investigated. In this study, we report that LMP1 alters the expression profile of APOBEC3s(A3s), host deaminases that introduce consecutive C-to-U mutations (hypermutation). In vitro, LMP1 induces APOBEC3B (A3B) and 3F(A3F), in a nasopharyngeal cell line, AdAH. Overexpression of LMP1, A3B, or A3F induces mtDNA hypermutation, which is also detectable from NPC specimens. Expression of LMP1 and A3B in NPC was correlated with neck metastasis. These results provide evidence as to which LMP1 induces A3s and mtDNA hypermutation, and how LMP1 facilitates metastasis is also discussed.

Indexed as

DNA, MitochondrialHerpesvirus 4, HumanMutationAPOBEC DeaminasesCell Line, TumorCell Transformation, ViralDisease SusceptibilityEpstein-Barr Virus InfectionsHost-Pathogen InteractionsHumansImmunohistochemistryNasopharyngeal NeoplasmsNeoplasm StagingViral Matrix ProteinsAPOBEC3 proteins, humanAPOBEC DeaminasesDNA, MitochondrialEBV-associated membrane antigen, Epstein-Barr virusViral Matrix ProteinsAPOBECEBV-LMP1mitochondrial DNAnasopharyngeal cancer

Identifiers

PMID32815637
PMCPMC7571841
OpenAlexW3061382445

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.