Evidence map›Paper›PMID 32815636›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2020

Blood pressure, T cells, and mortality in people with HIV in Tanzania during the first 2 years of antiretroviral therapy.

Karl G Reis, Bernard Desderius, Justin Kingery, Annet Kirabo, Abel Makubi, Christina Myalla, Myung Hee Lee, Saidi Kapiga, Robert N Peck

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. CD4Circulation · 2025
    Article
  15. ComparingAIDS care · 2025
    Article
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Karl G ReisCenter for Global Health, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-9509-4526
Bernard DesderiusDepartment of Medicine, Weill Bugando School of Medicine, Mwanza, Tanzania.
Justin KingeryCenter for Global Health, Weill Cornell Medical College, New York, NY, USA.
Annet KiraboDivision of Clinical Pharmacy, Vanderbilt University Medical Center, Nashville, TN, USA.
Abel MakubiDepartment of Medicine, Weill Bugando School of Medicine, Mwanza, Tanzania.
Christina MyallaMwanza Intervention Trials Unit (MITU), Mwanza, Tanzania.
Myung Hee LeeCenter for Global Health, Weill Cornell Medical College, New York, NY, USA.
Saidi KapigaMwanza Intervention Trials Unit (MITU), Mwanza, Tanzania.
Robert N PeckCenter for Global Health, Weill Cornell Medical College, New York, NY, USA.
Cornell University · USBugando Medical Centre · TZMwanza Intervention Trials Unit · TZVanderbilt University Medical Center · US

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
Global Health Research Training in HIV and TuberculosisK24AI098627 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI FITZGERALD, DANIEL W · 2012 to 2022
$1.8M
Hypertension in HIV-Infected Tanzanians: Time Course and PathogenesisK01TW010281 · FIC · WEILL MEDICAL COLL OF CORNELL UNIV · PI PECK, ROBERT N · 2015 to 2019
$689k
FIC NIH HHS K01 TW010281Medical Research Council G0901756Medical Research Council MR/R00255X/1NCATS NIH HHS UL1 TR000457NCATS NIH HHS UL1 TR002384NIAID NIH HHS K24 AI098627NIH HHS NIH K01TW010281NIH HHS NIH K24AI098627NIH HHS NIH UL1TR000457
6 · The paper itself

Abstract

Cardiovascular disease is now a leading cause of mortality in people with HIV (PWH). High blood pressure is the major driver of cardiovascular disease. Despite this, little is known about blood pressure in PWH during the early years of antiretroviral therapy (ART). In this prospective cohort study in Tanzania, the authors conducted unobserved blood pressure measurements at enrollment, 3, 6, 12, 18, and 24 months in 500 PWH initiating ART and 504 HIV-uninfected adults. The authors excluded measurements taken on antihypertensive medications. Although PWH had a significantly lower blood pressure before ART initiation, they had a significantly greater increase in blood pressure during the first 2 years of ART compared to HIV-uninfected controls. Blood pressure correlates in PWH differed from HIV-uninfected controls. In PWH, lower baseline CD4

Indexed as

HIV InfectionsAdultBlood PressureCD4 Lymphocyte CountFemaleHumansHypertensionMaleProspective StudiesTanzaniaT-Lymphocytesblood pressureCD4+ T cellglobal healthHIV

Identifiers

PMID32815636
PMCPMC7722134
OpenAlexW3080867282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.