ArticleJournal of the American Geriatrics Society2020
Association Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).
Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The effect of tetrahydrocannabinol:cannabidiol oromucosal spray on cognition: a systematic review.European journal of clinical pharmacology · 2023Pooled it
- Article
- Effect of apolipoprotein E ε4 and its modification by sociodemographic characteristics on cognitive measures in South Asians from LASI-DAD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Polygenic Risk Scores for Alzheimer's Disease and General Cognitive Function Are Associated With Measures of Cognition in Older South Asians.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Does ethnicity influence dementia, stroke and mortality risk? Evidence from the UK Biobank.Frontiers in public health · 2023Article
- Article
- Changing demography and the challenge of dementia in India.Nature reviews. Neurology · 2021Review
- Introduction to LASI-DAD: The Longitudinal Aging Study in India-Diagnostic Assessment of Dementia.Journal of the American Geriatrics Society · 2020Article
- New Insights and Knowledge on Cognition and Dementia from Population-Based Cohort of Older Adults in India.Journal of the American Geriatrics Society · 2020Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
BACKGROUND/
objectivesGenetic factors play an important role in Alzheimer's disease (AD) and cognitive aging. However, it is unclear whether risk loci identified in European ancestry (EA) populations have similar effects in other groups, such as South Asians.
designWe investigated the allelic distribution and cognitive associations of 56 known AD risk single-nucleotide polymorphisms (SNPs) identified from three EA genome-wide association studies (EA-GWASs) in a South Asian population. Single SNP and genetic risk score (GRS) associations with measures of episodic memory were assessed.
settingThe Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD).
participantsA total of 906 LASI-DAD participants from diverse states in India. MEASUREMENTS: Participants were genotyped using the Illumina Global Screening Array and imputed with 1000G Phase 3v5. Cognitive measures included total learning and delayed word recall.
resultsAlthough only a few SNPs were significantly associated with memory scores (P < .05), effect estimates from the EA-GWAS and the LASI-DAD showed moderate correlation (0.35-0.88) in the expected direction. GRSs were also associated with memory scores, although percentage variation explained was small (0.1%-0.6%).
conclusionsDiscrepancies in allele frequencies and cognitive association results suggest that genetic factors found predominantly through EA-GWASs may play a limited role in South Asians. However, the extent of differences in the genetic architecture of AD and cognition in EA and South Asians remains uncertain. There is also a critical need to perform a more comprehensive assessment of the mutational spectrum of South Asia to identify novel genetic variants associated with AD and cognition in this population. J Am Geriatr Soc 68:S45-S53, 2020.
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