ArticleJournal of the American Geriatrics Society2020
Cognitive Function and Cardiometabolic-Inflammatory Risk Factors Among Older Indians and Americans.
Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Seven routine blood markers predict five-year mortality in older Indians: a risk score from the LASI-DAD cohort.Research square · 2026Article
- Cardiometabolic Risk Factors and Cognitive Impairment Among Community-Dwelling Older Adults in Rural India: A Cross- Sectional Analysis of the Longitudinal Ageing Study in India (LASI) Wave 1.Research square · 2026Article
- Cardiometabolic-Inflammatory Risk Factors and Cognitive Decline Among Older Indians-Report From a Nationally Representative, Longitudinal Study.Journal of the American Geriatrics Society · 2026Article
- Diabetes and cognitive health in India: a nationally representative survey of adults aged 45 years and older.BMJ open · 2025Article
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- From dementia prevention research to global FINGER-based multi-domain interventions and implementation strategies.Cerebral circulation - cognition and behavior · 2025Review
- Independent and joint associations of cardiometabolic multimorbidity and depression on cognitive function: findings from multi-regional cohorts and generalisation from community to clinic.The Lancet regional health. Western Pacific · 2024Article
- The Association Between Cardiometabolic Risk and Cognitive Function Among Older Americans and Chinese.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Effect of apolipoprotein E ε4 and its modification by sociodemographic characteristics on cognitive measures in South Asians from LASI-DAD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Harmonization of four biomarkers across nine nationally representative studies of older persons.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Characterizing Multimorbidity Prevalence and Adverse Outcomes in Ethnically and Culturally Diverse Sub-Populations in India: Gaps, Opportunities, and Future Directions.International journal of environmental research and public health · 2024Review
- Anemia, hemoglobin concentration and cognitive function in the Longitudinal Ageing Study in India-Harmonized Diagnostic Assessment of Dementia (LASI-DAD) and the Health and Retirement Study.medRxiv : the preprint server for health sciences · 2024Article
- Clustering of Cardiometabolic Risk Factors and Dementia Incidence in Older Adults: A Cross-Country Comparison in England, the United States, and China.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Changing demography and the challenge of dementia in India.Nature reviews. Neurology · 2021Review
- The Association of Cognitive and Visual Function in a Nationally Representative Study of Older Adults in India.Neuroepidemiology · 2021Article
- Design and Methodology of the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).Journal of the American Geriatrics Society · 2020Article
- Introduction to LASI-DAD: The Longitudinal Aging Study in India-Diagnostic Assessment of Dementia.Journal of the American Geriatrics Society · 2020Article
- New Insights and Knowledge on Cognition and Dementia from Population-Based Cohort of Older Adults in India.Journal of the American Geriatrics Society · 2020Article
- Real-world effectiveness of dimethyl fumarate versus fingolimod in a cohort of patients with multiple sclerosis using standardized, quantitative outcome metrics.Multiple sclerosis journal - experimental, translational and clinicalArticle
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesTo investigate how cardiometabolic-inflammatory risk factors are related to cognition among older adults in India and the United States.
designThe Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD) and the Harmonized Cognitive Assessment Protocol of the Health and Retirement Study (HRS-HCAP) in the United States conducted an in-depth assessment of cognition, using protocols designed for international comparison.
settingCognitive tests were conducted in hospital or household settings in India and in household settings in the United States.
participantsRespondents aged 60 years and older from LASI-DAD (N = 1,865) and respondents aged 65 years and older from HRS-HCAP (N = 2,111) who provided venous blood specimen. MEASUREMENTS: We used total composite scores from the common cognitive tests administered. Cardiovascular risk was indicated by systolic and diastolic blood pressure, pulse rate, pro-B-type natriuretic peptide (proBNP), and homocysteine. Metabolic risk was measured by body mass index, glycosylated hemoglobin (HbA1c), high-density lipoprotein cholesterol, and lipoprotein (a) (only in India). Inflammatory risk was indicted by white blood cell count, C-reactive protein, albumin, and uric acid (only in India).
resultsThe distribution of both total cognition scores and of cardiometabolic risk factors differed significantly between India and the United States. In both countries, lower cognition was associated with older age, lower education, elevated homocysteine, elevated proBNP, and lower albumin levels. The associations between HbA1c levels and cognitive measures were statistically significant in both countries, but in the opposite direction, with a coefficient of 1.5 (P < .001) in India and -2.4 (P < .001) in the United States for one percentage increase in absolute HbA1c value.
conclusionCardiometabolic-inflammatory biomarkers are associated with cognitive functional levels in each country, but the relationships may vary across countries. J Am Geriatr Soc 68:S36-S44, 2020.
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