Evidence map›Paper›PMID 32815516›Full record

ArticleeLife2020

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in

Russell P Swift, Krithika Rajaram, Cyrianne Keutcha, Hans B Liu, Bobby Kwan, Amanda Dziedzic, Anne E Jedlicka, Sean T Prigge

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A picomolar inhibitor of theAntimicrobial agents and chemotherapy · 2024
    Article
  8. A pyruvate transporter in the apicoplast of apicomplexan parasites.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. TheeLife · 2024
    Article
  10. Article
  11. Article
  12. The mitochondrion ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. GeneTargeter: AutomatedThe CRISPR journal · 2022
    Article
  18. Updated List of Transport Proteins inFrontiers in cellular and infection microbiology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Russell P SwiftDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.
Krithika RajaramDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.ORCID 0000-0003-4830-5471
Cyrianne KeutchaDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.
Hans B LiuDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.
Bobby KwanDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.
Amanda DziedzicDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.
Anne E JedlickaDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.
Sean T PriggeDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.ORCID 0000-0001-9684-1733
Johns Hopkins University · US

Funding

Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Determinants of apicoplast maintenance in malaria parasitesR01AI125534 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sean Taylor PRIGGE · 2016 to 2026
$3.9M
HopkinsPREP: Research, Community, Professional Training and Personal GrowthR25GM109441 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WILSON, KATHERINE L · 2015 to 2024
$3.2M
Malaria and Mosquito/Tick-borne DiseasesT32AI138953 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DAVID Joseph SULLIVAN · 2019 to 2026
$2.0M
Roles of Lipoate Pathways in Plasmodium SurvivalR01AI065853 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PRIGGE, SEAN TAYLOR · 2006 to 2010
$2.0M
Conditional probes of secretory protein function in malaria parasitesR21AI101589 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PRIGGE, SEAN TAYLOR · 2012 to 2013
$428k
NIAID NIH HHS R01 AI065853NIAID NIH HHS R01 AI125534NIAID NIH HHS R21 AI101589NIAID NIH HHS T32 AI007417NIAID NIH HHS T32 AI138953NIGMS NIH HHS R25 GM109441
6 · The paper itself

Abstract

The apicoplast of

Indexed as

ApicoplastsPlasmodium falciparumProtozoan ProteinsPyruvate KinaseProtozoan ProteinsPyruvate Kinaseapicoplastbiochemistrycarbon metabolismchemical biologyinfectious diseasemalariamicroarraymicrobiologyP. falciparumplasmodiumPyruvate Kinase

Identifiers

PMID32815516
PMCPMC7556864
OpenAlexW3053144730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.