Evidence map›Paper›PMID 32815100›Full record

ArticleJournal of assisted reproduction and genetics2020

Association study between single-nucleotide variants rs12097821, rs2477686, and rs10842262 and idiopathic male infertility risk in Serbian population with meta-analysis.

Vucic Nemanja, Dobrijevic Zorana, Kotarac Nevena, Matijasevic Suzana, Vukovic Ivan, Budimirovic Branko, Djordjevic Mirka, Savic-Pavicevic Dusanka, Brajuskovic Goran

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Vucic NemanjaCentre for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO Box 43, Belgrade, 11 158, Serbia.
Dobrijevic ZoranaCentre for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO Box 43, Belgrade, 11 158, Serbia.
Kotarac NevenaCentre for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO Box 43, Belgrade, 11 158, Serbia.
Matijasevic SuzanaCentre for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO Box 43, Belgrade, 11 158, Serbia.
Vukovic IvanClinic of Urology, Clinical Center of Serbia, Belgrade, Serbia.
Budimirovic Branko"Academian Vojin Sulovic" Centre for In Vitro Fertilisation, General Hospital Valjevo, Valjevo, Serbia.
Djordjevic Mirka"Academian Vojin Sulovic" Centre for In Vitro Fertilisation, General Hospital Valjevo, Valjevo, Serbia.
Savic-Pavicevic DusankaCentre for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO Box 43, Belgrade, 11 158, Serbia.
Brajuskovic GoranCentre for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO Box 43, Belgrade, 11 158, Serbia. brajuskovic@bio.bg.ac.rs.ORCID http://orcid.org/0000-0002-3935-6755
University of Belgrade · RSCentar za Promociju Nauke · RS

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 173016
6 · The paper itself

Abstract

purposeA genome-wide association study conducted in the Han Chinese population identified three single nucleotide variants rs12097821, rs2477686, and rs10842262 as being significantly associated with non-obstructive azoospermia. Our aim was to evaluate the possible association between these susceptibility loci and idiopathic male infertility risk in the Serbian population.

methodsA case-control study was conducted on 431 male individuals from the Serbian population divided into two groups. The case group consisted of 208 males diagnosed with oligoasthenozoospermia or non-obstructive azoospermia, while the control group involved 223 fertile men who have fathered at least one child.

resultsAccording to codominant (P

conclusionOur results show variants rs2477686 and rs10842262 to be significantly associated with male infertility in the Serbian population. Nevertheless, case-control studies in other populations are needed to validate their association with infertility in males diagnosed with oligoasthenozoospermia and non-obstructive azoospermia.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyAdultAllelesAzoospermiaCase-Control StudiesGene FrequencyGenetics, PopulationGenotypeHumansInfertility, MaleMaleNuclear ProteinsPeroxinsPolymorphism, Single NucleotideProtein-Arginine N-MethyltransferasesNuclear ProteinsPeroxinsPEX10 protein, humanPRMT6 protein, humanProtein-Arginine N-MethyltransferasesReceptors, Cytoplasmic and NuclearSOX5 protein, humanSOXD Transcription FactorsGenetic associationMale infertilityMeta-analysisrs10842262rs12097821rs2477686

Identifiers

PMID32815100
PMCPMC7642064
OpenAlexW3051252047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.