ArticleMolecular and cellular biochemistry2021
Transcriptional regulation of the ER stress-inducible gene Sec16B in Neuro2a cells.
Article in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Identification of SEC16B as a novel regulator of glucose homeostasis.Diabetologia · 2025Article
- Transcriptional regulation of solute carrier family 6 member 9 gene.Molecular biology reports · 2025Article
- Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity.Scientific reports · 2023Article
- Comprehensive Bioinformatics Analysis to Reveal Key RNA Targets and Hub Competitive Endogenous RNA Network of Keratoconus.Frontiers in genetics · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Endoplasmic reticulum (ER) stress responses have been demonstrated to play important roles in maintaining various cellular functions and to underlie many tissue dysfunctions. In this study, we identified Sec16B as an ER stress-inducible gene by microarray analysis of brefeldin A (BFA)-inducible genes in a mouse neuroblastoma cell-line, Neuro2a. Sec16B mRNA was induced by treatment with the ER stress-inducing reagents thapsigargin (Tg) and brefeldin A in a time-dependent manner. In the genomic sequence of the mouse Sec16B gene, we found an unfolded protein response element (UPRE), which is well conserved between humans and mice. Using luciferase reporter analyses, we showed that the UPRE in the mouse Sec16B gene was functional and responded well to ER stress-inducing stimuli and spliced XBP1 (sXBP1)-overexpression. In addition, a unique ATF4-responsive sequence within the first intron of the mouse Sec16B gene was characterized. Our study may help to elucidate the regulation of trafficking through the ER-Golgi apparatus and the biogenesis of ER-derived intracellular organelles.
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