Evidence map›Paper›PMID 32815025›Full record

ArticleArchives of gynecology and obstetrics2021

Testosterone serum levels are not predictive of maternal virilization in hyperreactio luteinalis.

Mateja Condic, Waltraut M Merz, Ulrich Gembruch, Dietrich Klingmüller, Birgit Stoffel-Wagner, Ramona Dolscheid-Pommerich

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mateja CondicDepartment of Obstetrics and Prenatal Medicine, University Bonn Medical School, Venusberg Campus 1, Building 31, 53127, Bonn, Germany. mateja.condic@ukbonn.de.ORCID 0000-0002-7456-9625
Waltraut M MerzDepartment of Obstetrics and Prenatal Medicine, University Bonn Medical School, Venusberg Campus 1, Building 31, 53127, Bonn, Germany.
Ulrich GembruchDepartment of Obstetrics and Prenatal Medicine, University Bonn Medical School, Venusberg Campus 1, Building 31, 53127, Bonn, Germany.
Dietrich KlingmüllerDivision of Endocrinology and Diabetes, Department of Medicine I, University Bonn Medical School, Venusberg Campus 1, 53127, Bonn, Germany.
Birgit Stoffel-WagnerInstitute of Clinical Chemistry and Clinical Pharmacology, University Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Ramona Dolscheid-PommerichInstitute of Clinical Chemistry and Clinical Pharmacology, University Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
University of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElevated concentrations of circulating testosterone are present in hyperreactio luteinalis (HL), a pregnancy-specific, self-limited condition. HL is associated with maternal virilization in about 30% of cases. The correlation between testosterone levels and maternal virilization has not yet been quantified. Our aim was to identify a testosterone cut-off level which may allow to predict maternal virilization.

methodsA literature research was performed. Publications were chosen if serum testosterone concentrations and presence or absence of maternal virilization was mentioned. Additionally, we report serial levels of steroids analyzed by Liquid chromatography-tandem mass spectrometry (LC-MS/MS) in one case of HL managed at our institution.

resultsIn all, 31 cases fulfilled the search criteria. We found significant overlap between testosterone levels in asymptomatic women and women with signs of virilization (range 6.2-37.3 nmol/l and 13.7-197.5 nmol/l, respectively). The method applied for testosterone analysis was mentioned in three reports only. Peak serum testosterone concentration in our case was 120.3 nmol/l.

conclusionFrom the available data, maternal virilization in HL cannot be predicted by the level of circulating testosterone. However, comparability of results is hampered by the analytical methods applied. LC-MS/MS should preferably be used for reporting concentrations of circulating testosterone.

Indexed as

AdultChromatography, LiquidFemaleHumansOvarian CystsPregnancyPregnancy ComplicationsTandem Mass SpectrometryTestosteroneVirilismTestosteroneElectrochemiluminescence immunoassayHyperandrogenismHyperreactio luteinalisLiquid chromatography–tandem mass spectrometryMaternal virilizationPregnancy-associated virilization

Identifiers

PMID32815025
PMCPMC7854420
OpenAlexW3064252692

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.