Evidence map›Paper›PMID 32814902›Full record

ArticleNature2020

Immune-evasive human islet-like organoids ameliorate diabetes.

Eiji Yoshihara, Carolyn O'Connor, Emanuel Gasser, Zong Wei, Tae Gyu Oh, Tiffany W Tseng, Dan Wang, Fritz Cayabyab, Yang Dai, Ruth T Yu and 4 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 209 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 1 pooled it
37.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 1 synthesis or guideline pooled it, 320 citations in OpenAlex.

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  12. FXR and BET signaling orchestrate to protect β cells.bioRxiv : the preprint server for biology · 2026
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149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Eiji YoshiharaGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Carolyn O'ConnorFlow Cytometry Core Facility, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3301-7912
Emanuel GasserGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Zong WeiGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-4691-0101
Tae Gyu OhGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Tiffany W TsengGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Dan WangGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Fritz CayabyabGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Yang DaiGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Ruth T YuGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9527-9627
Christopher LiddleStorr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead, New South Wales, Australia.ORCID http://orcid.org/0000-0003-3936-6790
Annette R AtkinsGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Michael DownesGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Ronald M EvansGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. evans@salk.edu.ORCID http://orcid.org/0000-0002-9986-5965
Salk Institute for Biological Studies · USThe University of Sydney · AU

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8M
Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Engineering human islet-like organoids for transplantationR01DK120480 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2018 to 2021
$3.4M
BD FACSAria Fusion for Flow Cytometry Core FacilityS10OD023689 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2018 to 2018
$530k
A role of chromatin remodeling complexes in beta cell dysfunctionK01DK120808 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WEI, ZONG · 2019 to 2021
$421k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA014195NIDDK NIH HHS K01 DK120808NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK120480NIEHS NIH HHS P42 ES010337NIH HHS S10 OD023689
6 · The paper itself

Abstract

Islets derived from stem cells hold promise as a therapy for insulin-dependent diabetes, but there remain challenges towards achieving this goal

Indexed as

Immune EvasionAnimalsB7-H1 AntigenCell LineDiabetes Mellitus, ExperimentalEpigenesis, GeneticFemaleGlucoseGraft RejectionHeterograftsHomeostasisHumansImmune ToleranceInsulin SecretionIslets of LangerhansIslets of Langerhans TransplantationB7-H1 AntigenCD274 protein, humanGlucoseWnt4 ProteinWNT4 protein, human

Identifiers

PMID32814902
PMCPMC7872080
OpenAlexW3068518905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.