ArticleNature2020
Genetic and functional insights into the fractal structure of the heart.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 3 pooled it
9.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- A systematic review of GWAS on CMR imaging traits: genetic insights into cardiovascular structure, function, and diseases.EBioMedicine · 2025Pooled it
- A large genome-wide association study of QT interval length utilizing electronic health records.Genetics · 2022Pooled it
- Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function.Nature genetics · 2022Pooled it
- Inferring multi-organ genetic connections using imaging and clinical data through Mendelian randomization.Nature biomedical engineering · 2026Article
- Artificial intelligence-enhanced electrocardiography for the prediction of future type 2 diabetes mellitus: a model-development and multicentre validation study.European heart journal. Digital health · 2026Article
- Human genetics across levels of biological organization.Nature reviews. Genetics · 2026Review
- RBM20 variants disrupt CaSignal transduction and targeted therapy · 2026Article
- Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging.Cell genomics · 2026Review
- Left Ventricular Isoperimetric Properties in Hypertrophic Cardiomyopathy: A CMR-Based Analysis of Ventricular Geometry.Diagnostics (Basel, Switzerland) · 2026Article
- Left ventricular excessive trabeculation: pathophysiology, diagnostic challenges, and prognostic significance.Heart failure reviews · 2026Review
- Quantitative ventricular trabeculation assessment in cardiac MRI: optimised blood-pool segmentation, box-counting fractal analysis and non-fractal measurements.The international journal of cardiovascular imaging · 2026Article
- Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.Communications medicine · 2026Article
- How should we interpret excessive left ventricular trabeculation? Update on controversies from the cardiac imaging perspective.Insights into imaging · 2026Article
- A fractal pattern of hierarchical genetic population structure in mixed stocks across fish segregated by dams revealed by genomic resources for curimba Prochilodus lineatus.Journal of fish biology · 2026Article
- HistoGWAS: an AI-enabled framework for automated genetic analysis of tissue phenotypes in histology cohorts.Genome biology · 2026Article
- Mitral Annular Disjunction and Coalescing Myths in Cardiology.Arrhythmia & electrophysiology review · 2026Article
- REECAP: Contrastive learning of retinal aging reveals genetic loci linking morphology to eye disease.medRxiv : the preprint server for health sciences · 2025Article
- Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.NPJ genomic medicine · 2025Article
- Preliminary investigation into the mechanical implications of excessive trabecularization in the left ventricle.Quantitative imaging in medicine and surgery · 2025Article
- Causal relationships between inflammatory mediators, sleep traits, and cardiac magnetic resonance imaging-derived cardiac phenotypes.Scientific reports · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 12 institutions in 6 countries.
Hannah V Meyer *Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. hmeyer@cshl.edu.ORCID http://orcid.org/0000-0003-4564-0899
Timothy J W Dawes *MRC London Institute of Medical Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-7871-524X
Marta Serrani *Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Wenjia BaiDepartment of Computing, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-2943-7698
Paweł TokarczukMRC London Institute of Medical Sciences, Imperial College London, London, UK.
Jiashen CaiDuke-National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-6988-1809
Antonio de MarvaoMRC London Institute of Medical Sciences, Imperial College London, London, UK.
Albert HenryInstitute of Health Informatics, University College London, London, UK.
R Thomas LumbersInstitute of Cardiovascular Science, University College London, London, UK.ORCID http://orcid.org/0000-0002-9077-4741
Jakob GiertenDepartment of Pediatric Cardiology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8143-1918
Thomas ThumbergerCentre for Organismal Studies, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8485-457X
Joachim WittbrodtCentre for Organismal Studies, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8550-7377
James S WareMRC London Institute of Medical Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-6110-5880
Daniel RueckertDepartment of Computing, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-5683-5889
Paul M MatthewsDepartment of Brain Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-1619-8328
Sanjay K PrasadNational Heart and Lung Institute, Imperial College London, London, UK.
Maria L CostantinoDepartment of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Milan, Italy.
Stuart A CookMRC London Institute of Medical Sciences, Imperial College London, London, UK.
Ewan BirneyEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.ORCID http://orcid.org/0000-0001-8314-8497
Declan P O'ReganMRC London Institute of Medical Sciences, Imperial College London, London, UK. declan.oregan@imperial.ac.uk.ORCID http://orcid.org/0000-0002-0691-0270
MRC London Institute of Medical Sciences · GBHeidelberg University · DEEuropean Bioinformatics Institute · GBImperial College London · GBRoyal Brompton & Harefield NHS Foundation Trust · GBNational University of Singapore · SGPolitecnico di Milano · ITSingHealth · SGSt Bartholomew's Hospital · GBUK Dementia Research Institute · GBUniversity College London · GBUniversity of Cambridge · GB
Funding
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9MThe medaka Kiyosu panel: dissecting GxE effects of environmental chemicalsR01ES029917 · NIEHS · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI BIRNEY, EWAN, GOLDSTONE, JARED VERRILL · 2019 to 2023
$2.1MBritish Heart Foundation NH/17/1/32725British Heart Foundation RE/18/4/34215British Heart Foundation RG/19/6/34387British Heart Foundation SP/17/11/32885Medical Research Council G0900897Medical Research Council G9409531Medical Research Council G9409634Medical Research Council G9901399Medical Research Council MC_PC_17114Medical Research Council MC_U120085815Medical Research Council MC_UP_1102/19Medical Research Council MC_UP_1102/20Medical Research Council MR/K501013/1Medical Research Council MR/M003191/1Medical Research Council MR/N026934/1Medical Research Council MR/S003754/1NCI NIH HHS P30 CA045508NIEHS NIH HHS R01 ES029917NIEHS NIH HHS R01ES029917-02Wellcome Trust 107469Wellcome Trust 107469/Z/15/Z
Abstract
The inner surfaces of the human heart are covered by a complex network of muscular strands that is thought to be a remnant of embryonic development
Indexed as
FractalsGenetic Predisposition to DiseaseAdultAgedAnimalsCardiovascular DiseasesCytoskeletonGene Knockout TechniquesGenetic LociGenome-Wide Association StudyHeartHemodynamicsHumansMiddle AgedMyocardiumOryzias
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.