Evidence map›Paper›PMID 32814896›Full record

ArticleNature2020

Unique homeobox codes delineate all the neuron classes of C. elegans.

Molly B Reilly, Cyril Cros, Erdem Varol, Eviatar Yemini, Oliver Hobert

Abstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed.

  1. Article
  2. Regulatory logic of neuronal differentiation in theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. A pilot study for whole proteome tagging inbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. A conservedbioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. TAG-IN, a swappable strategy for endogenous gene tagging inbioRxiv : the preprint server for biology · 2026
    Article
  15. Article
  16. Article
  17. Regulatory logic of neuronal identity specification inbioRxiv : the preprint server for biology · 2025
    Article
  18. A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Molly B ReillyDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, NY, USA.
Cyril CrosDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, NY, USA.
Erdem VarolDepartment of Statistics, Columbia University, New York, NY, USA.
Eviatar YeminiDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, NY, USA.
Oliver HobertDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, NY, USA. or38@columbia.edu.ORCID http://orcid.org/0000-0002-7634-2854

Funding

Hormones: Molecular Mechanism of Action and FunctionsT32DK007328 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KOUSTENI, STAVROULA · 1986 to 2025
$7.8M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Translational Neuroscience Training Grant.T32MH015174 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DENNY, CHRISTINE ANN · 1985 to 2020
$4.0M
A nervous system-wide analysis of C. elegans homeobox gene functionR21NS106843 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HOBERT, OLIVER · 2018 to 2019
$429k
Do unique homeobox gene codes define all neuron classes of the C. elegans nervous system?F31NS105398 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REILLY, MOLLY BOOTH · 2018 to 2020
$135k
Howard Hughes Medical InstituteNIDDK NIH HHS T32 DK007328NIH HHS P40 OD010440NIMH NIH HHS T32 MH015174NINDS NIH HHS F31 NS105398NINDS NIH HHS R21 NS106843
6 · The paper itself

Abstract

It is not known at present whether neuronal cell-type diversity-defined by cell-type-specific anatomical, biophysical, functional and molecular signatures-can be reduced to relatively simple molecular descriptors of neuronal identity

Indexed as

Gene Expression RegulationGenes, HomeoboxAnimalsCaenorhabditis elegansGenomeHomeodomain ProteinsNervous SystemNeuronsHomeodomain Proteins

Identifiers

PMID32814896
PMCPMC7587405

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.