Evidence map›Paper›PMID 32814883›Full record

ArticleNature2020

APP gene copy number changes reflect exogenous contamination.

Junho Kim, Boxun Zhao, August Yue Huang, Michael B Miller, Michael A Lodato, Christopher A Walsh, Eunjung Alice Lee

Abstract readLetterComment
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Brain Somatic Mutation in Aging and Alzheimer's Disease.Annual review of genomics and human genetics · 2021
    Review
  9. Review
  10. Somatic copy number variants in neuropsychiatric disorders.Current opinion in genetics & development · 2021
    Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Junho KimDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Boxun ZhaoDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2337-5756
August Yue HuangDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Michael B MillerDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6205-3314
Michael A LodatoDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Christopher A WalshDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA. christopher.walsh@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-0156-2238
Eunjung Alice LeeDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA. ealice.lee@childrens.harvard.edu.

Funding

VASCULAR, PULMONARY AND RENAL INJURYT32HL007627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIMBRONE, MICHAEL A, MITCHELL, RICHARD N · 1985 to 2019
$12.7M
Cell Identity Determination In Human Brain: Somatic Mutation and Cell LineageR01NS032457 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Alice Eunjung Lee, Christopher A. Walsh · 1995 to 2026
$12.7M
Genome-Wide Somatic Mutation in Alzheimer's Disease Pathogenesis Using Single Neuron AnalysisK08AG065502 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI MILLER, MICHAEL B · 2020 to 2024
$848k
SINGLE-CELL ANALYSIS OF SOMATIC MUTATION IN AGING ANO NEUROOEGENERATIVE DISEASE IN THE HUMAN BRAINR00AG054748 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LODATO, MICHAEL ANTHONY · 2019 to 2021
$743k
The role of somatic mutation in neurodegenerative diseaseK01AG051791 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, EUNJUNG ALICE · 2016 to 2020
$655k
Single-cell analysis of somatic mutation in aging and neurodegenerative disease in the human brainK99AG054748 · NIA · BOSTON CHILDREN'S HOSPITAL · PI LODATO, MICHAEL ANTHONY · 2017 to 2018
$260k
NHLBI NIH HHS T32 HL007627NIA NIH HHS K01 AG051791NIA NIH HHS K08 AG065502NIA NIH HHS K99 AG054748NIA NIH HHS R00 AG054748NINDS NIH HHS R01 NS032457
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA Copy Number VariationsGene Dosage

Identifiers

PMID32814883
PMCPMC7704338

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.