ReviewNature reviews. Microbiology2021
Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections.
Review in Nature reviews. Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 454 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
454 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,292 citations in OpenAlex.
- Systematic review of antibacterial potential in calcium oxide and silicon oxide nanoparticles for clinical and environmental infection control.Journal of applied biomedicine · 2025Pooled it
- Advances in the Application of Multimodal Nano-Antimicrobial Strategies in Prosthetic Joint Infections: A Systematic Review.International journal of nanomedicine · 2025Pooled it
- Microfluidic-assembled curcumin ionizable lipid nanoparticles enhance aqueous delivery and antibiofilm activity againstInternational journal of pharmaceutics: X · 2026Article
- Gallate-oriented surface engineering of lignin nanoparticles for enhanced antibacterial activity.Materials today. Bio · 2026Article
- Curcumin Loaded ZIF 8 Nanomaterials Ameliorate Porcine Endometritis Like Lesions in a Mouse Model via Regulating Macrophage Polarization and Antibacterial Activity.Animals : an open access journal from MDPI · 2026Article
- Mytilus edulis-mediated green synthesis of selenium nanoparticles with antimicrobial and molluscicidal applications.Scientific reports · 2026Article
- Synthesis, Characterization, and Multifunctional Bioactivity of ZnO/CuO@Amoxicillin Nanocomposites: A Synergistic Nano-Platform With Potent Antioxidant, Anti-Inflammatory, Antidiabetic, and Anti-Cholinesterase Activities.Chemistry & biodiversity · 2026Article
- Engineering "Yin-Yang" Ag/AgCl-Polymer Nanotherapeutic for Tunable Silver Ion Release With Improved In Vivo Biocompatibility and Antimicrobial Potency.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- NIR-Assisted Multimodal Strategies for Enhanced Antibacterial Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Emerging Metal-Organic Frameworks (MOFs): Synthesis, Bioactivities, Preservation, Active Packaging/Sensing System, and Future Perspectives for Seafood Applications.Journal of food science · 2026Review
- Biofilm state transitions: quorum sensing inhibition and network destabilization.Applied microbiology and biotechnology · 2026Review
- Functional role of manganese nanoparticles in broiler diets: Impacts on growth, antioxidant status, immune response, blood minerals, digestive enzymes, carcass traits, and cecal bacterial counts.Poultry science · 2026Article
- Bibliometric mapping of scientific production on photodynamic therapy in cutaneous wounds: A web of science analysis.Lasers in medical science · 2026Review
- A biomimetic cascade nanoplatform for synergistic biofilm eradication and immune activation against MRSA.RSC advances · 2026Article
- Mild photothermal therapy ameliorates neurogenic bladder after sacral spinal cord injury via multi-target effects.Materials today. Bio · 2026Article
- HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dual-Action Nucleic Acid Nanoparticles: Innate Immune Activation and Silver Nanocluster-Mediated Targeting of Intracellular Bacteria.ACS nano medicine · 2026Article
- Liposome-Mediated Bacterial Ferroptosis-like Death: A Novel Paradigm for Antimicrobial Therapy.Antibiotics (Basel, Switzerland) · 2026Review
- Design, Synthesis, and Antitubercular Activity of Thiolutin-Cycloserine Hybrids: Reducing Cytotoxicity.Microorganisms · 2026Article
- Nanotechnology-Enabled Strategies to Overcome Antibiotic Resistance in Respiratory Infections: Mechanisms, Platforms, and Translational Challenges.Biomedicines · 2026Review
394 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Antibiotic-resistant bacterial infections arising from acquired resistance and/or through biofilm formation necessitate the development of innovative 'outside of the box' therapeutics. Nanomaterial-based therapies are promising tools to combat bacterial infections that are difficult to treat, featuring the capacity to evade existing mechanisms associated with acquired drug resistance. In addition, the unique size and physical properties of nanomaterials give them the capability to target biofilms, overcoming recalcitrant infections. In this Review, we highlight the general mechanisms by which nanomaterials can be used to target bacterial infections associated with acquired antibiotic resistance and biofilms. We emphasize design elements and properties of nanomaterials that can be engineered to enhance potency. Lastly, we present recent progress and remaining challenges for widespread clinical implementation of nanomaterials as antimicrobial therapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.