ArticleEuropean journal of clinical nutrition2021
Associations between maternal calcium intake from diet and supplements during pregnancy and the risk of preterm birth in a Chinese population.
Article in European journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Maternal calcium, phosphorus, and supplement intake before and during pregnancy and their association with preterm birth risk: based on a large cohort study.Journal of health, population, and nutrition · 2026Article
- Association between micronutrient supplementation during pregnancy and preterm birth: evidence from a large-scale children survey and Mendelian randomization study.Frontiers in public health · 2025Article
- Association of maternal metal exposure and psychological status with adverse pregnancy outcomes: a nested case-control study.Frontiers in public health · 2025Article
- Serum calcium level at 32 weeks of gestation could be applied as a predictor of preterm delivery: a retrospective study.European journal of medical research · 2024Article
- Article
- The prevalence of trimester-specific dietary supplements and associated factors during pregnancy: An observational study.Frontiers in pharmacology · 2023Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesPreterm birth is a global public health priority related to maternal nutrition. The effect of maternal calcium intake during pregnancy on preterm birth is inconclusive and data is lacking in China. We aimed to estimate the role of calcium intake from diet and supplements on preterm birth in the Chinese population.
methodsWe used data of 7195 women from a large-scale cross-sectional study in Northwest China. Dietary intake was evaluated via a validated food frequency questionnaire, and other information was collected by a structured questionnaire. Generalized estimating equation models were used to estimate the relationship between calcium intake and preterm birth.
resultsInadequate dietary calcium intake was universal in our population (85.9%), and no association was found between daily dietary calcium intake and preterm birth. Maternal calcium supplementation was significantly associated with reduced risk of preterm birth (OR 0.72, 95% CI 0.60, 0.87, P = 0.001), particularly among women who commenced calcium supplementation in the second and third trimester of pregnancy with longer duration (OR 0.62, 95% CI 0.42, 0.91, P = 0.015). Higher daily calcium intake from supplements was linked with lower preterm birth risk (every 100 mg increase: OR 0.87, 95% CI 0.79, 0.96, P = 0.004). There is a negative association between daily total calcium intake and preterm birth among calcium supplement users (every 100 mg increase: OR 0.91, 95% CI 0.84, 0.97, P = 0.007).
conclusionsIn conclusion, appropriate calcium supplementation during pregnancy could be beneficial in the prevention of preterm birth, and it might be suitable for implementing in low calcium intake areas of China.
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