Evidence map›Paper›PMID 32814838›Full record

ArticleLeukemia2021

Reduced red blood cell surface level of Factor H as a mechanism underlying paroxysmal nocturnal hemoglobinuria.

Lingjun Zhang, Jin Y Chen, Cassandra Kerr, Brian A Cobb, Jaroslaw P Maciejewski, Feng Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lingjun ZhangDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Jin Y ChenDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Cassandra KerrTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
Brian A CobbDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Jaroslaw P MaciejewskiTranslational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
Feng LinDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. linf2@ccf.org.ORCID http://orcid.org/0000-0002-7202-1447
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · USCase Western Reserve University · US

Funding

Therapeutic Implications of Molecular Defects in Bone Marrow FailureR35HL135795 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MACIEJEWSKI, JAROSLAW P. · 2017 to 2023
$5.7M
Regulatory Mechanisms of Glycoprotein SialylationR01GM115234 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Brian A Cobb · 2016 to 2026
$5.1M
Local inhibition of complement to improve MSC-based therapy for diabetesR01DK103581 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI HAMILTON, THOMAS A., LIN, FENG C · 2015 to 2018
$1.4M
Development of a novel antibody-drug conjugate for treating T-cell lymphoma.R41CA275639 · NCI · ABCON THERAPEUTICS, INC. · PI LIN, FENG C · 2022 to 2022
$403k
Development of new models of AMDR21EY031087 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI LIN, FENG C · 2019 to 2019
$348k
NCI NIH HHS R41 CA275639NEI NIH HHS R21 EY031087NHLBI NIH HHS R35 HL135795NIDDK NIH HHS R01 DK103581NIGMS NIH HHS R01 GM115234
6 · The paper itself

Abstract

The absence of the cell-surface complement inhibitors CD55 and CD59 is considered the mechanism underlying the complement-mediated destruction of affected red blood cells (RBCs) in paroxysmal nocturnal hemoglobinuria (PNH) patients, but Factor H (FH), a fluid-phase complement inhibitor, has also been proposed to be involved. However, the status of FH on the PNH patient RBC surface is unclear and its precise role in PNH pathogenesis remains to be further defined. In this study, we identified significantly lower levels of surface-bound FH on the affected CD59

Indexed as

Disease SusceptibilityAdultAgedAnimalsBiomarkersComplement Factor HComplement System ProteinsDisease Models, AnimalErythrocyte MembraneErythrocytesFlow CytometryHemoglobinuria, ParoxysmalHemolysisHumansMiceMice, KnockoutBiomarkersCFH protein, humanComplement Factor HComplement System Proteins

Identifiers

PMID32814838
PMCPMC7892643
OpenAlexW3050399216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.