ArticleThe American journal of pathology1988
c-myc protein in normal tissue. Effects of fixation on its apparent subcellular distribution.
Article in The American journal of pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 78 citations in OpenAlex.
- Novel cytological model for the identification of early oral cancer diagnostic markers: The carcinoma sequence model.Oncology letters · 2022Article
- Genome-wide expression of the residual lung reacting to experimental Pneumonectomy.BMC genomics · 2021Article
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- Dynamic architecture of the purinosome involved in human de novo purine biosynthesis.Biochemistry · 2015Article
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- c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study.Journal of oral and maxillofacial pathology : JOMFP · 2013Article
- Co-overexpression of bcl-2 and c-myc in uterine cervix carcinomas and premalignant lesions.European journal of histochemistry : EJH · 2011Article
- Immunohistochemical analysis of c-myc, c-jun and estrogen receptor in normal, hyperplastic and neoplastic endometrium.Pathology oncology research : POR · 2005Article
- Expression of Bcl-2 and amplification of c-myc are frequent in basaloid squamous cell carcinomas of the esophagus.The American journal of pathology · 1999Article
- Bcl-2 and c-Myc, but not bax and p53, are expressed during human medullary thyroid tumorigenesis.The American journal of pathology · 1998Article
- Immunohistochemical demonstration of c-myc oncogene product in middle ear cholesteatoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 1995Article
- Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Comparative analysis of p53 and c-myc expression and cell proliferation in human hepatocellular carcinomas--an enhanced immunohistochemical approach.Journal of cancer research and clinical oncology · 1993Article
- C-myc oncogene product p62 in ovarian mucinous neoplasms.Journal of clinical pathology · 1990Article
- Correlation Between Low Cytoplasmic Expression of XBP1 and the Likelihood of Surviving Hepatocellular Carcinoma.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The c-myc protein is thought to be a DNA-associated nuclear protein. However, immunohistochemical studies on normal or tumor tissues have shown conflicting findings on its subcellular distribution. By using various fixation procedures on cytospin preparations of HL60 cells, the authors found the subcellular distribution of the c-myc protein to be dependent on the method of fixation. When studying mouse tissues in frozen sections using a biotinylated monoclonal antibody against the c-myc protein, they found the protein to be widely distributed in various normal adult mouse tissues, in most cases localized to the nucleus. However, when these tissues were studied after formalin fixation and paraffin embedding, a loss of nuclear staining was observed concurrent with the appearance of c-myc protein immunoreactivity in the cytoplasm. It is concluded that immunohistochemical studies on the expression of this oncogene should take into consideration the effects of fixation when its subcellular distribution is being examined.
Indexed as
Identifiers
3281469PMC1880581W95078003What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.