ArticleAnnals of clinical microbiology and antimicrobials2020
Safety and bactericidal efficacy of cold atmospheric plasma generated by a flexible surface Dielectric Barrier Discharge device against Pseudomonas aeruginosa in vitro and in vivo.
Article in Annals of clinical microbiology and antimicrobials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Piezoelectric cold atmospheric plasma inactivates dairy cattle bacteria and potentiates antibiotics in vitro.Applied microbiology and biotechnology · 2026Article
- Effectiveness of cold atmospheric plasma on Staphylococcus Aureus colonies on living animal tissue surface.PloS one · 2026Article
- Gas plasma-induced bacterial PAMP release promotes skin cancer cell death.Cell death & disease · 2025Article
- Treatment of Clinically Important Bacteria With Cold Atmospheric Plasma.Microbial biotechnology · 2025Review
- The inherent defects of cold atmospheric plasma for the treatment of burns.Frontiers in pharmacology · 2025Article
- Branched tetrameric lactoferricin peptides modified with diaminopropionic acid exhibit potent antimicrobial and wound-healing activities.Frontiers in pharmacology · 2025Article
- The Successful Treatment of Multi-Resistant Colonized Burns with Large-Area Atmospheric Cold Plasma Therapy and Dermis Substitute Matrix-A Case Report.European burn journal · 2024Article
- Cold Atmospheric Pressure Plasma Solutions for Sustainable Food Packaging.International journal of molecular sciences · 2024Review
- Two separate mechanisms are involved in membrane permeabilization during lipid oxidation.Biophysical journal · 2023Article
- Article
- Modulation of the Tumor-Associated Immuno-Environment by Non-Invasive Physical Plasma.Cancers · 2023Review
- Argon Humidification Exacerbates Antimicrobial and Anti-MRSA kINPen Plasma Activity.Life (Basel, Switzerland) · 2023Article
- Exploring the potential of cold plasma therapy in treating bacterial infections in veterinary medicine: opportunities and challenges.Frontiers in veterinary science · 2023Review
- The potential of gas plasma technology for targeting breast cancer.Clinical and translational medicine · 2022Review
- Inactivation and sensitization of Pseudomonas aeruginosa by microplasma jet array for treating otitis media.NPJ biofilms and microbiomes · 2021Article
- Cold Atmospheric Plasma Promotes Regeneration-Associated Cell Functions of Murine Cementoblasts In Vitro.International journal of molecular sciences · 2021Article
- Development of Antimicrobial Phototreatment Tolerance: Why the Methodology Matters.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCold atmospheric plasma (CAP), which is ionized gas produced at atmospheric pressure, could be a novel and potent antimicrobial therapy for the treatment of infected wounds. Previously we have shown that CAP generated with a flexible surface Dielectric Barrier Discharge (sDBD) is highly effective against bacteria in vitro and in ex vivo burn wound models. In the current paper, we determined the in vitro and in vivo safety and efficacy of CAP generated by this sDBD device.
methodsThe effect of CAP on DNA mutations of V79 fibroblasts was measured using a hypoxanthine-guanine-phosphoribosyltransferase (HPRT) assay. Furthermore, effects on cell proliferation, apoptosis and DNA damage in ex vivo burn wound models (BWMs) were assessed using immunohistochemistry. Next, 10
resultsExposure of V79 fibroblasts to CAP did not increase the numbers of mutated colonies. Additionally, the number of proliferative, apoptotic and DNA damaged cells in the BWMs was comparable to that of the unexposed control. Exposure of PAO1 to CAP for 2 min resulted in the complete elimination of bacteria in vitro. Contrarily, CAP treatment for 6 min of rat wounds colonized with PAO1 did not effectively reduce the in vivo bacterial count.
conclusionsCAP treatment was safe but showed limited efficacy against PAO1 in our rat wound infection model.
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